Results 311 to 320 of about 160,198 (339)
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Nonpeptide Angiotensin II Receptor Antagonists
American Journal of Hypertension, 1990Although the most direct way to interfere with the renin-angiotensin system (RAS) is at the level of the angiotensin II (AII) receptor, the currently available AII receptor antagonists are peptides still retaining significant agonistic properties with the obvious drawbacks of limited stability and lack of oral activity.
P B, Timmermans +8 more
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Angiotensin II receptor antagonists and receptor subtypes
Trends in Endocrinology & Metabolism, 1992Recently discovered nonpeptide angiotensin II receptor antagonists represent a new class of potential drugs for the treatment of hypertension and congestive heart failure. Further, these antagonists have been successfully used as selective research tools for physiologic studies of angiotensin H and defining angiotensin II receptor subtypes.
P C, Wong +5 more
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1994
The diversity of specific physiological effects elicited by angiotensin II1,2 (ANG II) poses a simple but important question: Are they mediated by a single or multiple type of receptors? While workers on ANG II action expected more than one subtype as suggested by the presence of the dithiothreitolsensitive and -insensitive receptors, exceeding ...
Tadashi Inagami +2 more
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The diversity of specific physiological effects elicited by angiotensin II1,2 (ANG II) poses a simple but important question: Are they mediated by a single or multiple type of receptors? While workers on ANG II action expected more than one subtype as suggested by the presence of the dithiothreitolsensitive and -insensitive receptors, exceeding ...
Tadashi Inagami +2 more
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The Angiotensin II Receptor and the Actions of Angiotensin II
Journal of Cardiovascular Pharmacology, 1990Angiotensin II (Ang II) is a potent effector peptide of the renin-angiotensin system that exerts a wide variety of physiological actions on the cardiovascular, renal, endocrine, and central and peripheral nervous systems. Angiotensin exerts its actions by binding to specific receptors in the plasma membrane of various tissues.
M J, Peach, D E, Dostal
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Angiotensin II Receptor Antagonists
High Blood Pressure & Cardiovascular Prevention, 2007Stroke is a devastating disease that heavily affects overall cardiovascular mortality and quality of life in surviving patients, and has a relevant burden on healthcare systems. Recent data derived both from large epidemiological surveys and from the analysis of events occurring in the clinical trials on hypertension, performed over the last 10 years ...
Giuliano Tocci +2 more
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Angiotensin-II Receptor Blockers
2000As described in the previous chapter, the renin-angiotensin system (RAS) plays an important role in the body’s regulation of arterial blood pressure. The effector hormone of the RAS is angiotensin II, which maintains the systemic vascular resistance and extracellular fluid volume through its direct and indirect vasoconstrictive and blood volume ...
William H. Frishman +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2004
The peptide angiotensin(Ang) II exerts hemodynamic, and renal as well as cardiovascular structural effects. Multiple lines of evidence have suggested the existence of several Ang II receptor subtypes. Recent evidence has revealed that the functions of the AT1 and AT2 receptors are mutually antagonistic in various cells and tissues.
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The peptide angiotensin(Ang) II exerts hemodynamic, and renal as well as cardiovascular structural effects. Multiple lines of evidence have suggested the existence of several Ang II receptor subtypes. Recent evidence has revealed that the functions of the AT1 and AT2 receptors are mutually antagonistic in various cells and tissues.
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Journal of the American Society of Nephrology : JASN, 1999
This review examines the recent progress in the field of angiotensin receptors. Multiplicity of these receptors was demonstrated initially on the basis of pharmacologic differences and then confirmed by expression cloning. AT1 receptors are predominant in the adult.
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This review examines the recent progress in the field of angiotensin receptors. Multiplicity of these receptors was demonstrated initially on the basis of pharmacologic differences and then confirmed by expression cloning. AT1 receptors are predominant in the adult.
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Angiotensin II Receptor Inhibition
Archives of Internal Medicine, 1996Angiotensin II receptor antagonists represent a new class of drugs that provide a sitespecific blockade of the effects of angiotensin II. Losartan potassium, the first compound of this drug class, has recently become available in the United States. The clinical experience with angiotensin II receptor antagonists has demonstrated that these drugs are ...
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Angiotensin II receptor blockers
Coronary Artery Disease, 1999H, Thai, T, Raya
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