Results 51 to 60 of about 160,198 (339)

Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney

International Journal of Nephrology and Renovascular Disease, 2020
Zsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U.
Razga Z
doaj  

Preeclampsia, the Renin-Angiotensin-Aldosterone System and beyond [PDF]

, 2015
__Abstract__ The renin-angiotensin-aldosterone system (RAAS) plays an essential role in the regulation of blood pressure and body fluid homeostasis, but also contributes importantly to the pathophysiology of hypertension, renal disease and heart ...
Verdonk, K. (Koen)
core   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

ACE-versus chymase-dependent angiotensin II generation in human coronary arteries: a matter of efficiency? [PDF]

, 2003
OBJECTIVE: The objective of this study was to investigate ACE- and chymase-dependent angiotensin I-to-II conversion in human coronary arteries (HCAs).
Boomsma, F. (Frans), Danser, A.H.J. (Jan), Garrelds, I.M. (Ingrid), Saxena, P.R. (Pramod Ranjan), Scalbert, E., Stegmann, A.P.A. (Sander), Tom, B. (Beril)   +6 more
core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor

Frontiers in Endocrinology, 2022
Prior investigation shows an increase in the activity of both hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin system (RAS) in diabetic patients.
Amanda da Silva Chaves, Nathalia Santos Magalhães, Daniella Bianchi Reis Insuela, Patrícia Machado Rodrigues E. Silva, Marco Aurélio Martins, Vinicius Frias Carvalho, Vinicius Frias Carvalho   +6 more
doaj   +1 more source

Nonpeptide angiotensin II-receptor antagonists.

Japanese Journal of Pharmacology, 1994
The renin-angiotensin system (RAS) is known to play a very important role in cardiovascular diseases. The present state of the research on orally active nonpeptide angiotensin II (A II)-receptor antagonists and their pharmacological characterization will be reviewed.
Y, Inada, T, Wada, Y, Shibouta, K, Nishikawa   +3 more
openaire   +2 more sources

Pathophysiological Role of Caveolae in Hypertension [PDF]

, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver, Gollasch, Maik, Kaßmann, Mario, Lian, Xiaoming, Matthaeus, Claudia   +4 more
core   +2 more sources