Angiotensin II Type 1 Receptor Blockers [PDF]
Circulation, 2001 In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
M. Burnier
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Advances in the allostery of angiotensin II type 1 receptor [PDF]
Cell & Bioscience, 2023 Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang +4 more
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Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor [PDF]
Frontiers in Cardiovascular Medicine, 2023 Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi +7 more
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Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundBoth the adrenergic and renin‐angiotensin systems contribute to orthostatic circulatory homeostasis, which is impaired in postural orthostatic tachycardia syndrome (POTS).
Xichun Yu +9 more
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The angiotensin II type 1 receptor and receptor-associated proteins [PDF]
Cell Research, 2001 The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D. Guo, Yu Lin Sun, P. Hamet, T. Inagami
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Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy [PDF]
Frontiers in Physiology, 2017 Aims: Renal renin-angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DN). Angiotensin II (Ang II) type 1 receptor (AT1R) blockade elevates (pro)renin, which may bind to (pro)renin receptor (PRR) and exert receptor ...
Lin Zhang +7 more
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miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis [PDF]
Cell Death DiscoverySeveral microRNAs play vital roles in placental development. miR-155 has been implicated in placental development and can directly interact with a variety of targets, including angiotensin type II receptor 1 (AT1R) (Agtr1) mRNA.
Anya L. Arthurs +8 more
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MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation: implications for innovative type 2 diabetes mellitus management. [PDF]
World J Diabetes, 2023 Papadopoulos KI, Papadopoulou A, Aw TC.
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Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells [PDF]
Anais da Academia Brasileira de Ciências, 2019 : Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor.
YING YU +7 more
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Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats [PDF]
Hypertension, 2011 Pregnant women who subsequently develop preeclampsia are highly sensitive to infused angiotensin (Ang) II; the sensitivity persists postpartum. Activating autoantibodies against the Ang II type 1 (AT 1 ) receptor are present in preeclampsia.
K. Wenzel +20 more
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