Results 41 to 50 of about 39,438,208 (302)

Angiogenesis "in vitro" of the healthy mouse heart under hypoxia : the role of Angiotensin II and Nitric Oxide [PDF]

, 2005
Angiogenesis is the process by which blood microvessels are formed from existing ones. Angiogenesis is required for development. It is also important for reducing myocardial hypoxia due to coronary and ischemic heart disease; in myocardial infarction ...
Munk, Veronica Cecilia
core   +1 more source

Pharmacological and clinical profile of telmisartan, a selective angiotensin II type-1 receptor blocker

Folia Pharmacologica Japonica, 2004
Telmisartan (Micardis) is a potent, long-lasting, nonpeptide angiotensin II type-1 (AT(1)) receptor blocker (ARB) that is indicated for the treatment of essential hypertension. In receptor binding studies, telmisartan showed a high affinity and selectivity for the human AT(1) receptors compared with AT(2) receptors and a slower dissociation rate from ...
CHACHIN, Motohiko, OHMURA, Tsuyoshi, HAYASHI, Naoyuki, NISHIMURA, Yoichiro, SATOH, Hisashi   +4 more
openaire   +3 more sources

Combined Therapy With a Calcium Channel Blocker and an Angiotensin II Type 1 Receptor Blocker

The Journal of Clinical Hypertension, 2008
Fixed‐dosed combination regimens consisting of a calcium channel blocker and an angiotensin II type 1 receptor blocker represent a new addition to the available antihypertensive treatment options. Clinical trials demonstrate that both the dihydropyridine calcium channel blocker amlodipine and angiotensin II receptor blockers are effective agents for ...
openaire   +3 more sources

Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension

Clinical and Experimental Hypertension, 2019
Backgrounds and aims: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to ...
Mo-Li Zhu, Rui-Li Sun, He-Yun Zhang, Fan-Rong Zhao, Guo-Pin Pan, Chong Zhang, Ping Song, Peng Li, Jian Xu, Shuangxi Wang, Ya-Ling Yin   +10 more
doaj   +1 more source

Impact of age on characteristics, performance measures and outcomes of inpatients for heart failure in Beijing, China

ESC Heart Failure, 2023
Aims This study aims to provide representative information on heart failure (HF) patients in China, especially older adults aged ≥75 years. We aim to clarify the age‐related discrepancies in performance measures and the modifying effect of age on the ...
Cong Yuan, Liu He, Xin Du, Chao Jiang, Shi‐Jun Xia, Xin Zhao, Song‐Nan Li, Cai‐Hua Sang, De‐Yong Long, Jian‐Zeng Dong, Chang‐Sheng Ma   +10 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Clinical Comparative Trials of Angiotensin II Type 1 (AT 1 )-Receptor Blockers

Blood Pressure, 2001
Three characteristics of antihypertensive medication are pivotal in therapy for a patient with hypertension: potency and efficacy, duration of action, and the incidence of side-effects. The relatively new class of AT1-receptor blockers all display placebo-like tolerability and, as a class, their antihypertensive efficacy compares well with other ...
openaire   +2 more sources

Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent [PDF]

Hypertension, 2010
In the present study, we tested the hypothesis that the renoprotective effect of an angiotensin receptor blocker depends on the angiotensin II type 1 (AT 1 ) receptor on podocytes. For this purpose, we generated podocyte-specific knockout mice for the AT 1 gene ( Agtr1a
Taiji, Matsusaka, Takako, Asano, Fumio, Niimura, Masaru, Kinomura, Akihiro, Shimizu, Ayumi, Shintani, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +8 more
openaire   +2 more sources

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source