Angiotensin II type 1 receptor blocker-induced immune thrombocytopenia: a case report [PDF]
Journal of Medical Case Reports, 2013 The development of thrombocytopenia after a dose increase in losartan and subsequently after switching the patient to valsartan is reported.A 61-year-old Caucasian man presented with epistaxis and gingival bleeding of three weeks duration. Laboratory evaluation revealed a hemoglobin level of 144g/L, a leukocyte count of 16.2×109 cells/L (72.51 ...
Patel, Dhiren K. +2 more
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Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy
The Scientific World Journal, 2008 Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
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The angiotensin II Type 1 receptor blocker losartan in clinical practice: a review
Clinical Therapeutics, 1996 Blockade of angiotensin II receptors was first achieved in the 1970s using a peptide, saralasin acetate. Although it was effective in lowering blood pressure, it required parenteral administration and had a short duration of action and partial agonist activity.
H P, Gavras, C M, Salerno
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Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis [PDF]
Hepatology, 2007 Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma.
Akira, Hirose +10 more
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Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. [PDF]
PLoS ONE, 2013 Angiotensin II has progressively been considered to play an important role in the development of liver fibrosis, although the mechanism isn't fully understood.
Yu-Sheng Li +6 more
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The Role of Renin–Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review
Life, 2023 Diabetic cardiomyopathy refers to myocardial dysfunction in type 2 diabetes, but without the traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease.
João Pedro Thimotheo Batista +3 more
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Frontiers in Physiology, 2019 Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis.
Lakmie S. Gunarathne +3 more
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Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]
, 2014 GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G. +41 more
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Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]
PLoS ONE, 2014 Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb +3 more
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Biomedicines, 2022 Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT1R). Its simple chemical structure possesses a negatively charged triazene segment that is homologous to the ...
John M. Matsoukas +12 more
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