Results 1 to 10 of about 35,349,291 (244)

Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]

Kidney Research and Clinical Practice, 2023
Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim   +3 more
doaj   +1 more source

Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu, Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy, Robert M. Carey, Ceereena Ubaida‐Mohien, Brian O'Rourke, Luigi Ferrucci, David A. Bennett, Jeremy Walston, Peter Abadir   +12 more
doaj   +1 more source

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

Molecular Medicine, 2020
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
doaj   +1 more source

Advances in the allostery of angiotensin II type 1 receptor

Cell & Bioscience, 2023
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu   +4 more
doaj   +1 more source

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Frontiers in Pharmacology, 2020
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members ...
Natalia L. Rukavina Mikusic, Mauro G. Silva, Angélica M. Pineda, Mariela M. Gironacci   +3 more
doaj   +1 more source

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor

Frontiers in Cardiovascular Medicine, 2023
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal   +7 more
doaj   +1 more source

ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Российский кардиологический журнал, 2016
Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood.
I. S. Mykhailichenko
doaj   +1 more source

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies

Kidney International Reports, 2019
Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non–human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific ...
Meghan H. Pearl, Jonathan Grotts, Maura Rossetti, Qiuheng Zhang, David W. Gjertson, Patricia Weng, David Elashoff, Elaine F. Reed, Eileen Tsai Chambers   +8 more
doaj   +1 more source

Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats

Biomedicines, 2023
The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park, Jo-Young Son, Hak-Kyun Kim, Yu-Mi Kim, Jin-Sook Ju, Min-Jeong Jo, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn   +8 more
doaj   +1 more source