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Angiotensin Type 2 Receptors in the Cardiovascular System
High Blood Pressure & Cardiovascular Prevention, 2007Angiotensin II (Ang II) exerts its effects by acting on two receptors: the angiotensin type 1 receptor (AT1R) and the angiotensin type 2 receptor (AT2R). Whereas AT1R seems to mediate most of the recognised actions of Ang II, it appears that AT2R opposes, in part, the actions mediated by AT1R.
Carmine Savoia, Ernesto L Schiffrin
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Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors
Current Pharmaceutical Design, 2013Renin-angiotensin system (RAS) plays a key role in pathogenesis of cardiovascular disease and in the responsiveness for various types of medications. A large number of genetic investigations have been carried out to examine the association between gene variants of RAS and predisposition to cardiovascular diseases, such as hypertension, coronary artery ...
Tomohiro, Katsuya, Ryuichi, Morishita
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[Angiotensin-2 type 1 receptors (AT1R) and cancers].
Nephrologie & therapeutique, 2013Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to ...
Dolley-Hitze, Thibault +8 more
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Angiotensin 2 type 2 receptor activity and ischemic stroke severity
Neurology, 2005Drugs that increase angiotensin 2 formation, including thiazides, calcium channel blockers, and angiotensin 2 type 1 (AT1) receptor blockers, may be more effective in stroke prevention than angiotensin 2 suppressive drugs such as angiotensin-converting enzyme inhibitors and beta-blockers.To assess whether angiotensin 2 formation increasing drugs reduce
B, Ovbiagele +6 more
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[Angiotensin II type 1 and type 2 receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2009The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
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Angiotensin II type 2 receptor stimulation
2014Background This study is the first to examine the effect of direct Ang II type 2 (AT2) receptor stimulation on post infarct cardiac function with the use of the novel nonpeptide AT2 receptor agonist compound 21 (C21). Methods and Results Myocardial infarction (MI) was induced in Wistar rats by permanent ligation of the left coronary artery.
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