Results 41 to 50 of about 174,002 (143)
Roles and functions of Atp6ap2 in the brain
Neural Regeneration Research, 2018 The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke +1 more
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Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]
PLoS ONE, 2016 Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda +12 more
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Neuroprotective effect of angiotensin II type 2 receptor during cerebral ischemia/reperfusion
Neural Regeneration Research, 2016 Angiotensin II type 2 receptor (AT2R) activation has been shown to protect against stroke, but its precise mechanism remains poorly understood. We investigated whether the protective effect of AT2R against ischemia/reperfusion injury is mediated by the ...
Chun-ye Ma, Lin Yin
doaj +1 more source
Clinics, 2014 OBJECTIVE: To validate the importance of the angiotensin II receptor isotypes and the lymphatic vessels in systemic sclerosis and idiopathic pulmonary fibrosis.
Edwin Roger Parra +2 more
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The angiotensin II type 2 receptor and the kidney
Journal of the Renin-Angiotensin-Aldosterone System, 2009 Recent knowledge demonstrated that the renin-angiotensin system (RAS) functions as a local renal paracrine system. All components of the RAS are present within the kidney and include angiotensinogen, renin, angiotensin I, angiotensin-converting enzymes, angiotensin II, the angiotensin II type 1 (AT 1
openaire +2 more sources
The Angiotensin II Type 2 Receptor in Brain Functions: An Update
International Journal of Hypertension, 2012 Angiotensin II (Ang II) is the main active product of the renin-angiotensin system (RAS), mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the type 2 (AT2) receptor.
Marie-Odile Guimond, Nicole Gallo-Payet
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Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat [PDF]
Hypertension, 2006 Whereas angiotensin (Ang) II is the major effector peptide of the renin–angiotensin system, its metabolite, des-aspartyl1-Ang II (Ang III), may also have biologic activity. We investigated the effects of renal interstitial (RI) administration of candesartan (CAND), a specific Ang II type 1 receptor (AT1) blocker, with and without coinfusion of PD ...
Shetal H, Padia +3 more
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Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. [PDF]
PLoS ONE, 2012 ObjectivesThe role of angiotensin II type 2 (AT(2)) receptor stimulation in the pathogenesis of insulin resistance is still unclear. Therefore we examined the possibility that direct AT(2) receptor stimulation by compound 21 (C21) might contribute to ...
Kousei Ohshima +11 more
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Molecular structure and function of angiotensin type 2 receptor
Kidney International, 1994 More than two isoforms have been identified for angiotensin receptors based on their ligand selectivity. The objective of this study is to determine the molecular structure of angiotensin type 2 receptor (AT2), whose physiological functions are still an enigma despite extensive studies on its distribution in fetal tissues.
Kambayashi, Yoshikazu +3 more
openaire +2 more sources
Cells, 2021 Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the ...
Babak Saravi +10 more
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