Results 1 to 10 of about 213,515 (192)

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor [PDF]

Frontiers in Endocrinology, 2022
The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Mohammed Akli Ayoub, Rebecca J. Hertzman, Rebecca J. Hertzman, Heng B. See, Heng B. See, Rekhati S. Abhayawardana, Rekhati S. Abhayawardana, Ruth M. Seeber, Ruth M. Seeber, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger   +15 more
doaj   +2 more sources

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists [PDF]

Biomolecules, 2020
Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II).
Silvana Vasile, Anders Hallberg, Jessica Sallander, Mathias Hallberg, Johan Åqvist, Hugo Gutiérrez-de-Terán   +5 more
doaj   +4 more sources

Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency [PDF]

Frontiers in Cardiovascular Medicine, 2021
There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects ...
Michelle Lin, Robyn A. Roth, Beth A. Kozel, Robert P. Mecham, Carmen M. Halabi   +4 more
doaj   +2 more sources

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +2 more sources

Macrophage angiotensin II type 2 receptor triggers neuropathic pain. [PDF]

Proc Natl Acad Sci U S A, 2018
SignificanceNeuropathic pain is a widespread problem that is undermanaged by currently available analgesic drugs. An antagonist of the type II angiotensin II receptor (AT2R) reduces pain behaviors related to neuropathy, suggesting that angiotensin receptor signaling is involved in this pain.
Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW, Mohapatra DP.   +10 more
europepmc   +4 more sources

Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2017
Background Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment strategies. Recent studies have shown
Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu, Hongwei Li   +16 more
doaj   +2 more sources

Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats

Biomedicines, 2023
The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park, Jo-Young Son, Hak-Kyun Kim, Yu-Mi Kim, Jin-Sook Ju, Min-Jeong Jo, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn   +8 more
doaj   +1 more source

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G., Delbridge, Lea M. D.   +6 more
openaire   +3 more sources

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

Molecular Medicine, 2020
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
doaj   +1 more source

The angiotensin II type 2 receptor in renal disease [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2009
Suppression of angiotensin II formation by angiotensin-converting enzyme inhibitors or blockade of the angiotensin II receptor by angiotensin receptor blockers is a powerful therapeutic strategy to slow the progression of renal disease. However, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers provide only imperfect ...
Ulrich Otto, Wenzel, Christian, Krebs, Ralf, Benndorf   +2 more
openaire   +2 more sources