Tumor Biology, 2017 Local migration and long-distance metastasis is the main reason for higher mortality of ovarian cancer. Microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor–interacting protein is associated with tumor initiation and progression and ...
Ping Huang +3 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita +14 more
doaj +1 more source
Angiotensin AT1 Receptor-associated protein Arap1 in the Kidney Vasculature is Suppressed by Angiotensin II [PDF]
, 2012 Arap1 is a protein that interacts with angiotensin II type 1 (AT1) receptors and facilitates increased AT1 receptor surface expression in vitro. In the present study, we assessed the tissue localization and regulation of Arap1 in vivo.
Castrop, Hayo +7 more
core +1 more source
Angiotensin II Type 2 Receptor Gene Transfer Downregulates Angiotensin II Type 1a Receptor in Vascular Smooth Muscle Cells [PDF]
Hypertension, 2002 Two distinct subtypes of angiotensin (Ang) II receptors, type 1 (AT 1 ) and type 2 (AT 2 ), have been identified. Vascular smooth muscle cells (VSMCs) usually express AT 1 receptor. To elucidate the direct effects of the AT 2 receptor on the AT
Xue-Qing, Jin +9 more
openaire +2 more sources
Frontiers in Physiology, 2017 Aims: Renal renin-angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DN). Angiotensin II (Ang II) type 1 receptor (AT1R) blockade elevates (pro)renin, which may bind to (pro)renin receptor (PRR) and exert receptor ...
Lin Zhang +7 more
doaj +1 more source
AT(2) receptor-mediated vasodilation in the heart: effect of myocardial infarction [PDF]
, 2001 To investigate the functional consequences of postinfarct cardiac angiotensin (ANG) type 2 (AT(2)) receptor upregulation, rats underwent coronary artery ligation or sham operation and were infused with ANG II 3-4 wk later, when scar ...
Basdew, M. +6 more
core +1 more source
Angiotensin II Type 2 Receptor–Bradykinin B 2 Receptor Functional Heterodimerization [PDF]
Hypertension, 2006 Angiotensin II type 2 (AT 2 R) or bradykinin B 2 (B 2 R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT 2 R and B 2 R are simultaneously activated in vivo ...
Peter M, Abadir +3 more
openaire +2 more sources
Frontiers in Neuroscience, 2017 Objectives: Angiotensin II, glutamate and gamma-aminobutyric acid (GABA) interact within the rostral ventrolateral medulla (RVLM) and the paraventricular nucleus (PVN) modulating the central regulation of blood pressure and sympathetic tone.
Laura Légat +9 more
doaj +1 more source
Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries [PDF]
, 2010 Blood flow reduction induces inward remodeling of resistance arteries (RAs). This remodeling occurs in ischemic diseases, diabetes and hypertension. Nonetheless, the effect of flow reduction per se, independent of the effect of pressure or metabolic ...
A.L. Guihot +9 more
core +3 more sources
Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II [PDF]
, 2000 BACKGROUND: The mechanisms behind the beneficial effects of renin-angiotensin system blockade after myocardial infarction (MI) are not fully elucidated but may include interference with tissue angiotensin II (Ang II).
Boomsma, F. (Frans) +9 more
core +1 more source