Results 11 to 20 of about 192,985 (344)

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor [PDF]

Frontiers in Endocrinology, 2022
The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Mohammed Akli Ayoub, Rebecca J. Hertzman, Rebecca J. Hertzman, Heng B. See, Heng B. See, Rekhati S. Abhayawardana, Rekhati S. Abhayawardana, Ruth M. Seeber, Ruth M. Seeber, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger   +15 more
doaj   +4 more sources

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure.
E. Porrello, A. D'Amore, C. Curl, A. Allen, S. Harrap, W. Thomas, L. Delbridge   +6 more
semanticscholar   +7 more sources

Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency [PDF]

Frontiers in Cardiovascular Medicine, 2021
There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects ...
Michelle Lin, Robyn A. Roth, Beth A. Kozel, Robert P. Mecham, Carmen M. Halabi   +4 more
doaj   +4 more sources

Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling. [PDF]

Hypertension, 2021
The renin-angiotensin system is of vital significance not only in the maintenance of blood pressure but also because of its role in the pathophysiology of different organ systems in the body.
Fatima N, Patel SN, Hussain T.
europepmc   +2 more sources

Macrophage angiotensin II type 2 receptor triggers neuropathic pain. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance Neuropathic pain is a widespread problem that is undermanaged by currently available analgesic drugs. An antagonist of the type II angiotensin II receptor (AT2R) reduces pain behaviors related to neuropathy, suggesting that angiotensin ...
Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW, Mohapatra DP.   +10 more
europepmc   +2 more sources

Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists [PDF]

Biomolecules, 2020
Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II).
Silvana Vasile, Anders Hallberg, Jessica Sallander, Mathias Hallberg, Johan Åqvist, Hugo Gutiérrez-de-Terán   +5 more
doaj   +4 more sources

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +2 more sources

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium. [PDF]

Sci Rep, 2017
Despite increasing evidence suggesting that angiotensin II type 2 receptor (AT2R) may regulate tissue inflammation, no study has yet analyzed its possible implication in rheumatoid arthritis (RA) synovitis.
Terenzi R, Manetti M, Rosa I, Romano E, Galluccio F, Guiducci S, Ibba-Manneschi L, Matucci-Cerinic M.   +7 more
europepmc   +2 more sources

Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney. [PDF]

Hypertension, 2017
The actions of angiotensin II type 2 receptor (AT2R) and the receptor Mas (MasR) are complex but show similar pronatriuretic function; particularly, AT2R expression and natriuretic function are enhanced in obese/diabetic rat kidney.
Patel SN, Ali Q, Samuel P, Steckelings UM, Hussain T.   +4 more
europepmc   +2 more sources

The Angiotensin II Type 2 Receptor in Brain Functions: An Update [PDF]

International Journal of Hypertension, 2012
Angiotensin II (Ang II) is the main active product of the renin-angiotensin system (RAS), mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the type 2 (AT2) receptor.
Marie-Odile Guimond, Nicole Gallo-Payet
doaj   +3 more sources