Results 31 to 40 of about 130,850 (161)

Liver steatosis, cardiac and renal fibrosis, and hypertension in overweight rats: Angiotensin-(3–4)-sensitive hepatocardiorenal syndrome

Metabolism Open, 2022
Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations ...
Thuany Crisóstomo, Marco A.E. Pardal, Simone A. Herdy, Humberto Muzi-Filho, Debora B. Mello, Christina M. Takiya, Rafael Luzes, Adalberto Vieyra   +7 more
doaj   +1 more source

Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells. [PDF]

PLoS ONE, 2016
Transforming growth factor-β (TGF-β), via its receptors, induces epithelial-mesenchymal transition (EMT) and plays an important role in the development of renal tubulointersitial fibrosis.
Hui-Lin Guo, Xiao-Hui Liao, Qi Liu, Ling Zhang   +3 more
doaj   +1 more source

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

Frontiers in Bioscience, 2009
Angiotensin II (AngII) interacts with two receptor subtypes, AT1 and AT2, belonging to the seven transmembrane receptor superfamily. Pharmacological investigations initially suggested that AT2 receptors antagonize AT1 effects. Data from AT2 receptor transgenic and knock-out mice have not been entirely consistent with this interpretation.
Porrello, Enzo R., Delbridge, Lea M. D., Thomas, Walter G.   +2 more
openaire   +5 more sources

Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Clinical and Experimental Hypertension, 2018
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj   +1 more source

Mild hypothermia alleviates post-resuscitation cerebral injury in rats via modulating the balance of the renin–angiotensin system

Resuscitation Plus
Cardiac arrest and cardiopulmonary resuscitation represent a major cause of mortality. Cerebral ischemia–reperfusion injury following Cardiac arrest and cardiopulmonary resuscitation leads to severe neurological deficits and significantly worsens patient
Yongjing He, Qianqian Wu, Sisi Huang, Dan Wu, Yuansheng Zhan, Jiaqiang Deng, Beizhu Xu, Lu Xie, Junhui Zheng   +8 more
doaj   +1 more source

Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy

The Scientific World Journal, 2008
Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
doaj   +1 more source

Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice

Respiratory Research, 2008
Background The role of angiotensin II type 2 receptor (AT2) in pulmonary fibrosis is unknown. To evaluate the influence of angiotensin II type 1 receptor (AT1) and AT2 antagonists in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis. Methods We
Tagami Atsuro, Ichikawa Yukari, Takato Hazuki, Inuzuka Kanako, Nishizawa Yoriko, Yasui Masahide, Waseda Yuko, Fujimura Masaki, Nakao Shinji   +8 more
doaj   +1 more source

Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases

Cancer Cell International, 2010
Background Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases.
Wen Shu-wen, Chong Way W, Ager Eleanor I, Christophi Christopher   +3 more
doaj   +1 more source

The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?

Cells, 2021
Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the ...
Babak Saravi, Zhen Li, Corinna N. Lang, Bonaventura Schmid, Frauke K. Lang, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Hagen Schmal, Norbert Südkamp, Gernot M. Lang   +10 more
doaj   +1 more source

DAMAGE OF RENAL FUNCTION AND DYNAMICS OF DYSLIPIDEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH INSUFFICIENT GLYCEMIC COMPENSATION UNDER CONDITION OF CORRECTION OF HYPERTENSION WITH ANGIOTENSIN II RECEPTOR ANTAGONISTS

Український Журнал Нефрології та Діалізу, 2014
Damage of renal function and dynamics of dyslipidemia in patients with type 2 diabetes mellitus with insufficient glycemic compensation under condition of correction of hypertension with angiotensin II receptor antagonists   Introduction.
N.O. Pertseva
doaj   +1 more source