Results 51 to 60 of about 174,002 (143)
Biomedicines, 2022 Recent studies have shown that fascial fibroblasts are sensitive to different stimuli (biochemical or biophysical), promoting extracellular matrix remodeling, as well as synthetic activity.
Carmelo Pirri +8 more
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Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease
Clinical and Experimental Hypertension, 2018 Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
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Stem Cell Research, 2017 Obesity is often associated with high systemic and local activity of renin-angiotensin system (RAS). Mesenchymal stem cells of adipose tissue are the main source of adipocytes.
Veronika Y. Sysoeva +6 more
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The angiotensin II type 2 receptor in cardiovascular disease
Journal of the Renin-Angiotensin-Aldosterone System, 2009 Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system. The actions of Ang II have been implicated in many cardiovascular conditions, such as hypertension, atherosclerosis, coronary heart disease, restenosis, and heart failure. Ang II can act through two different receptors: Ang II type 1 (AT
Catherine A, Lemarié +1 more
openaire +2 more sources
Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency
Frontiers in Cardiovascular Medicine, 2021 There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects ...
Michelle Lin +4 more
doaj +1 more source
Scientific Reports, 2017 Rivaroxaban is an oral direct factor Xa inhibitor approved for the treatment of stroke and systemic thromboembolism in patients with non-valvular atrial fibrillation. Despite its efficacy, rivaroxaban therapy results in adverse effects and complications,
Dan Yang +5 more
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Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice
Respiratory Research, 2008 Background The role of angiotensin II type 2 receptor (AT2) in pulmonary fibrosis is unknown. To evaluate the influence of angiotensin II type 1 receptor (AT1) and AT2 antagonists in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis. Methods We
Tagami Atsuro +8 more
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Ontogeny of angiotensin type 2 and type 1 receptor expression in mice [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2012 In the current experiment, we determined angiotensin type 2 receptor (AT2R) and angiotensin type 1 receptor (AT1R) protein expression by western blot analysis in developing normal mice. The results indicate that: (1) in all detected brain regions and in the spinal cord, adult mice exhibited significantly higher AT2R expression and lower AT1R expression
Juan, Gao +6 more
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Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases
Cancer Cell International, 2010 Background Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases.
Wen Shu-wen +3 more
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American Journal of Physiology-Renal Physiology, 2010 Angiotensin type 1 (AT1) receptor blocker (ARB) ameliorates progression of chronic kidney disease. Whether this protection is due solely to blockade of AT1, or whether diversion of angiotensin II from the AT1to the available AT2receptor, thus potentially enhancing AT2receptor effects, is not known.
Takashi, Naito +7 more
openaire +3 more sources