Results 11 to 20 of about 181,641 (286)

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure.
Delbridge, Lea M. D., Harrap, Stephen B., D'Amore, Angelo, Curl, Claire L., Thomas, Walter G., Porrello, Enzo R., Allen, Andrew M.   +6 more
core   +6 more sources

Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis

American Journal of Physiology-Renal Physiology, 2009
Angiotensin type 1 (AT 1 ) receptor blocker (ARB) ameliorates progression of chronic kidney disease. Whether this protection is due solely to blockade of AT 1 , or whether diversion of angiotensin II from the AT 1 to the available AT 2 receptor, thus ...
Ma, Li-Jun, Tang, Yiwei, Zuo, Yiqin, Yang, Haichun, Han, Jee Young, Kon, Valentina, Naito, Takashi, Fogo, Agnes B.   +7 more
core   +4 more sources

Characterization of a mutant type-1 angiotensin II receptor

Kidney International, 1994
Characterization of a mutant type-1 angiotensin II receptor. We have used PCR to amplify the rat AT1 receptor from liver mRNA. The receptor DNA was subcloned into pcDNAI and a number of individual clones were transiently expressed in COS-7 cells.
Roche, Peter J., Coghlan, John P., Eddie, Lawrence W.   +2 more
core   +3 more sources

Angiotensin-[1-12] interacts with angiotensin type I receptors [PDF]

Neuropharmacology, 2014
Angiotensin-(1-12) [Ang-(1-12)], a newer member of angiotensin peptides, is proposed to be converted enzymatically to angiotensin I (Ang I) and to angiotensin II (Ang II); the latter being the bioactive peptide. We studied the Ang-(1-12) and Ang II responses in COS-7 cells or CHO cells transfected with 5 μg AT1R by monitoring [Ca(2+)]i using the Fluo-4.
Chan, King Hang, Chen, Yi Hung, Zhang, Ying, Wong, Yung Hou, Dun, Nae J.   +4 more
openaire   +3 more sources

Angiotensin Type 2 Receptor-Mediated Hypotension in Angiotensin Type-1 Receptor-Blocked Rats [PDF]

Hypertension, 2001
The type-2 (AT 2 ) angiotensin (Ang) II receptor has been characterized as potentially counterregulatory to the actions of Ang II at its type-1 (AT 1 ) receptor. We investigated the effects of Ang II and CGP-42112A (CGP), a selective peptide AT
R M, Carey, N L, Howell, X H, Jin, H M, Siragy   +3 more
openaire   +2 more sources

The angiotensin II type 1 receptor and receptor-associated proteins [PDF]

Cell Research, 2001
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D F, Guo, Y L, Sun, P, Hamet, T, Inagami
openaire   +2 more sources

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2017
Crystal structures of the human angiotensin II type 1 receptor (AT1R) complex with the antihypertensive agent ZD7155 (PDB id: 4YAY ) and the blood pressure medication Benicar (PDB id: 4ZUD ) showed that binding poses of both antagonists are similar. This finding implies that clinically used angiotensin receptor blocking (ARB) drugs may interact in a ...
Kh. Dhanachandra Singh, Hamiyet Unal, Russell Desnoyer, Sadashiva S. Karnik   +3 more
openaire   +2 more sources

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +1 more source

Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]

, 2007
Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E., Kellems, Rodney E, Mi, TieJuan, Xia, Yang, Sun, C, Hewett, Peter W, Abbasi, S, Zhou, CC, Mi, T, Abbasi, Shahrzad, Hewett, Peter, Xia, Y, Sun, ChunXiao, Kellems, RE, Ahmed, Asif, Hewett, Peter W., Xia, L, Ahmad, Shakil, Xia, Lingwei, Zhou, Cissy Chenyi   +19 more
core   +1 more source

Angiotensin II Type 1 Receptor Blockers [PDF]

Circulation, 2001
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
openaire   +3 more sources