Tubular Mas receptor mediates lipid-induced kidney injury [PDF]
Cell Death and Disease, 2021 Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood.
Yonglun Kong +10 more
doaj +5 more sources
Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS [PDF]
Hypertension, 2017 The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors of the protective arm of the renin-angiotensin system. They mediate strikingly similar actions.
Julia Leonhardt +2 more
exaly +5 more sources
Angiotensin (1-7) Induces Mas Receptor Internalization [PDF]
Hypertension, 2011 Angiotensin (Ang) (1-7) is the endogenous ligand for the G protein–coupled receptor Mas, a receptor associated with cardiac, renal, and cerebral protective responses. Physiological evidence suggests that Mas receptor (MasR) undergoes agonist-
Mariela M Gironacci, Hugo P Adamo
exaly +6 more sources
Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. [PDF]
PLoS ONE, 2014 Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis counteracts the deleterious actions of Ang II.
Hwee-Yeong Ng +6 more
doaj +4 more sources
Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension [PDF]
PLoS ONEThe angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis plays an important role in the regulation of blood pressure. G protein-coupled receptor kinase 4 (GRK4) has attracted more attentions by modulating G protein-coupled receptors and ...
Lin Chen +7 more
doaj +6 more sources
The expression of Mas-receptor of the renin–angiotensin system in the human eye [PDF]
Graefe's Archive for Clinical and Experimental Ophthalmology, 2015 The local renin-angiotensin system has been held to be expressed in many organs, including the eye. It has an important role in the regulation of local fluid homeostasis, cell proliferation, fibrosis, and vascular tone.
Kalesnykas, G. +7 more
exaly +5 more sources
Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis [PDF]
Frontiers in Pharmacology, 2021 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD).
Aya M. Mustafa +3 more
doaj +2 more sources
Angiotensin-(1-7) and Mas receptor in the brain [PDF]
Exploration of Medicine, 2021 The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher brain functions ...
Natalia L. Rukavina Mikusic +2 more
doaj +3 more sources
The Vasoactive Mas Receptor in Essential Hypertension. [PDF]
J Clin Med, 2020 The renin–angiotensin–aldosterone system (RAAS) has been studied extensively, and with the inclusion of novel components, it has become evident that the system is much more complex than originally anticipated. According to current knowledge, there are two main axes of the RAAS, which counteract each other in terms of vascular control: The classical ...
Povlsen AL +4 more
europepmc +4 more sources
Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases. [PDF]
Cell Cycle, 2023 MasR is a critical element in the RAS accessory pathway that protects the heart against myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by counteracting the effects of AT1R. This receptor is mainly stimulated by Ang 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2.
Molaei A, Molaei E, Hayes AW, Karimi G.
europepmc +3 more sources