Results 1 to 10 of about 40,064 (113)
Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis [PDF]
Frontiers in Pharmacology, 2021 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD).
Aya M. Mustafa +3 more
doaj +2 more sources
Tubular Mas receptor mediates lipid-induced kidney injury [PDF]
Cell Death and Disease, 2021 Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood.
Yonglun Kong +10 more
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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension [PDF]
PLoS ONEThe angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis plays an important role in the regulation of blood pressure. G protein-coupled receptor kinase 4 (GRK4) has attracted more attentions by modulating G protein-coupled receptors and ...
Lin Chen +7 more
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Lisinopril prevents bullous pemphigoid induced by dipeptidyl peptidase 4 inhibitors via the Mas receptor pathway [PDF]
Frontiers in Immunology, 2023 Recent studies have suggested that dipeptidyl peptidase 4 (DPP4) inhibitors increase the risk of development of bullous pemphigoid (BP), which is the most common autoimmune blistering skin disease; however, the associated mechanisms remain unclear, and ...
Keisuke Nozawa +7 more
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Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways [PDF]
Frontiers in Pharmacology, 2019 The MasR receptor (MasR) is an orphan G protein-coupled receptor proposed as a candidate for mediating the angiotensin (Ang)-converting enzyme 2-Ang-(1–7) protective axis of renin-angiotensin system.
Valeria Burghi +8 more
doaj +2 more sources
Renal vascular response to angiotensin 1-7 in rats: the role of Mas receptor [PDF]
Research in Pharmaceutical Sciences, 2018 Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal ...
Mehdi Nematbakhsh, Azam Mansouri
doaj +2 more sources
Pharmaceutics, 2022 Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD).
David Encinas-Basurto +4 more
doaj +1 more source
Renin-Angiotensin System: A Review of Historical Perspectives
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure ...
Gustavo B. Lamy +10 more
doaj +1 more source
Emerging Microbes and Infections, 2021 Since December 2019, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has changed our lives.
Serge Camelo +6 more
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