Lisinopril prevents bullous pemphigoid induced by dipeptidyl peptidase 4 inhibitors via the Mas receptor pathway [PDF]
Frontiers in Immunology, 2023 Recent studies have suggested that dipeptidyl peptidase 4 (DPP4) inhibitors increase the risk of development of bullous pemphigoid (BP), which is the most common autoimmune blistering skin disease; however, the associated mechanisms remain unclear, and ...
Keisuke Nozawa +7 more
doaj +2 more sources
Mas‐Related G Protein‐Coupled Receptor Member D Sustains Hypertension
MedCommHypertension and its associated complications, including vascular remodeling, pose a major burden on global public health. However, the role of Mas‐related G protein‐coupled receptor member D (MrgD) in hypertension remains incompletely understood.
Kun Zhao +8 more
doaj +2 more sources
Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]
PLoS ONE, 2013 Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira +9 more
doaj +3 more sources
Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation
Biochemical Pharmacology, 2017 The Mas receptor is involved in the angiotensin (Ang)-(1-7) vasodilatory actions by increasing nitric oxide production (NO). We have previously demonstrated an increased production of Ang-(1-7) in human umbilical vein endothelial cells (HUVEC) exposed to estradiol (E2), suggesting a potential cross-talk between E2 and the Ang-(1-7)/Mas receptor axis ...
Susana Vallejo +2 more
exaly +5 more sources
Angiotensin-(1-7) alleviates acute lung injury by activating the Mas receptor in neutrophil. [PDF]
Ann Transl Med, 2022 Wang L +7 more
europepmc +3 more sources
Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways [PDF]
Frontiers in Pharmacology, 2019 The MasR receptor (MasR) is an orphan G protein-coupled receptor proposed as a candidate for mediating the angiotensin (Ang)-converting enzyme 2-Ang-(1–7) protective axis of renin-angiotensin system.
Valeria Burghi +8 more
doaj +2 more sources
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling. [PDF]
Aging Cell, 2021 Dang R +7 more
europepmc +3 more sources
Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury [PDF]
International Journal of Hypertension, 2012 Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators.
Lívia Corrêa Barroso +9 more
doaj +2 more sources
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice. [PDF]
J NeuroinflammationBackground Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these patients.
Deng X +9 more
europepmc +2 more sources
The role of angiotensin‐(1–7) receptor Mas in spermatogenesis in mice and rats [PDF]
Journal of Anatomy, 2009 AbstractEvidence regarding the components of the renin–angiotensin (Ang) system suggests that this system plays an important role in male reproduction. However, there are few data available in the literature on the effects of Ang‐(1–7) on the male reproductive system.
Marcelo C. Leal +7 more
openalex +4 more sources