Results 41 to 50 of about 46,299 (322)

Role of the receptor Mas in macrophage-mediated inflammation in vivo [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceThe alternative renin–angiotensin system pathway, the angiotensin (Ang)-(1–7)/Mas axis, may counterbalance Ang II-mediated proinflammatory effects. To investigate the role of the Ang-(1–7)/Mas axis in immune cell function and inflammatory diseases in vivo, we used two different chronic inflammatory animal models.
Anna, Hammer, Guang, Yang, Juliane, Friedrich, Agnes, Kovacs, De-Hyung, Lee, Katharina, Grave, Stefanie, Jörg, Natalia, Alenina, Janina, Grosch, Jürgen, Winkler, Ralf, Gold, Michael, Bader, Arndt, Manzel, Lars C, Rump, Dominik N, Müller, Ralf A, Linker, Johannes, Stegbauer   +16 more
openaire   +2 more sources

Effects of intrarenal angiotensin 1–7 infusion on renal haemodynamic and excretory function in anaesthetised two‐kidney one‐clip and deoxycorticosterone acetate‐salt hypertensive rats

Experimental Physiology, 2023
This study investigated the action of angiotensin 1–7 (Ang (1–7)) on renal haemodynamic and excretory function in the two‐kidney one‐clip (2K1C) and deoxycorticosterone acetate (DOCA)‐salt rat models of hypertension, in which the endogenous renin ...
Elaine F. Barry, Mohammed H. Abdulla, Julie O'Neill, Sara AlMarabeh, Julie Beshara, Erin Parna‐Gile, Edward J. Johns   +6 more
doaj   +1 more source

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
core   +1 more source

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
Kathrin Rothe (386395), Ingrid Boekhoff, Ingrid Boekhoff (180345), Andreas Breit (180329), Solinski Hans Jürgen, Petermann, Franziska, Andreas Breit, Hans Jürgen Solinski (166922), Rothe Kathrin, Thomas Gudermann, Franziska Petermann, Boekhoff, Ingrid, Breit, Andreas, Boekhoff Ingrid, Rothe, Kathrin, Gudermann, Thomas, Gudermann Thomas, Breit Andreas, Thomas Gudermann (77426), Hans Jürgen Solinski, Petermann Franziska, Franziska Petermann (220017), Solinski, Hans Jürgen, Kathrin Rothe   +23 more
core   +1 more source

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

Journal of Pharmacological Sciences, 2021
Roles of the renin-angiotensin system in autophagy and ischemia/reperfusion (I/R) injury in the kidney have not been fully characterized. Here we examined the hypothesis that modest activation of the angiotensin II (Ang II) receptor upregulates autophagy
Hirohito Sugawara, Norihito Moniwa, Atsushi Kuno, Wataru Ohwada, Arata Osanami, Satoru Shibata, Yukishige Kimura, Koki Abe, Yufu Gocho, Masaya Tanno, Tetsuji Miura   +10 more
doaj   +1 more source

An ultrasensitive sorting mechanism for EGF receptor endocytosis [PDF]

, 2008
Background The EGF receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling ...
Roland Eils, Hoeller, Daniela, Ivayla Vacheva, Schmidt-Glenewinkel, Hannah, Eils, Roland, Hannah Schmidt-Glenewinkel, Đikić, Ivan, Vacheva, Ivayla, Daniela Hoeller, Ivan Dikic   +9 more
core   +1 more source

TO90 inhibits angiotensin II-induced inflammatory response by up-regulating ACE2/Ang-(1-7)/MAS receptor axis in human retinal pigment epithelial cells

Di-san junyi daxue xuebao, 2019
Objective To investigate whether TO90 inhibits angiotensin II (Ang Ⅱ)-induced inflammatory response by regulating the expressions of ACE2/Ang-(1-7)/MAS receptor axis in human retinal pigment epithelial cells.
MAI Yuxin, WANG Luoziyi, YU Peng, LIU Yanyao, LEI Bo   +4 more
doaj   +1 more source

Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells

Pharmacology Research & Perspectives, 2020
Angiotensin‐(1‐7), an endogenous agonist for the MasR, has been shown to interact with ang‐II AT1R and AT2R. Earlier we showed a physical and functional interaction between MasR and AT2R in response to their respective agonists ang‐(1‐7) and C21 ...
Sanket Patel, Tahir Hussain
doaj   +1 more source

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Frontiers in Physiology, 2019
Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis.
Lakmie S. Gunarathne, Peter W. Angus, Peter W. Angus, Chandana B. Herath   +3 more
doaj   +1 more source