Results 51 to 60 of about 46,299 (322)

Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor. [PDF]

PLoS ONE, 2015
Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members, namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular dysfunction.
Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Ibrahim F Benter   +5 more
doaj   +1 more source

Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

Endocrine Regulations, 2016
Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner.
Slamkova M, Zorad S, Krskova K
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source

Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat

Endocrine Regulations, 2019
Objective. Epidemiological studies confirm that hypertensive patients respond differently to renin-angiotensin system (RAS) inhibition depending on their gender.
Pidikova Paulina, Svitok Pavel, Herichova Iveta   +2 more
doaj   +1 more source

Dimerization of AT2 and Mas Receptors in Control of Blood Pressure

Current Hypertension Reports, 2018
Angiotensin type 2 receptor (AT2R) and receptor Mas (MasR) are part of the "protective arm" of the renin angiotensin system. Gene and pharmacological manipulation studies reveal that AT2R and MasR are involved in natriuretic, vasodilatory, and anti-inflammatory responses and in lowering blood pressure in various animal models under normal and ...
Sanket, Patel, Tahir, Hussain
openaire   +3 more sources

Angiotensina-(1-7) durante o processo inicial na cascata da ovulação em bovinos Angiotensin-(1-7) during the initial process of ovulatory cascade in cattle

Ciência Rural, 2012
O presente estudo teve como objetivo avaliar o efeito da Ang-(1-7) e de seu receptor (MAS) na regulação da ovulação. No experimento I, utilizando um modelo in vitro de cultivo de células foliculares, foi avaliado o efeito do tratamento com Ang-(1-7) ou ...
Joabel Tonellotto dos Santos, Bernardo Garziera Gasperin, Vitor Braga Rissi, Matheus Pedrotti De Cesaro, Alfredo Skrebsky Cezar, João Francisco Coelho de Oliveira, Paulo Bayard Dias Gonçalves   +6 more
doaj   +1 more source

Characteristics of Ang-(1–7)/Mas-Mediated Amelioration of Joint Inflammation and Cardiac Complications in Mice With Collagen-Induced Arthritis

Frontiers in Immunology, 2021
ObjectivesRheumatoid arthritis (RA) is a disabling disease with a high incidence that is regularly accompanied by cardiovascular complications. Several studies have suggested that renin–angiotensin–aldosterone system (RAAS) is closely associated with RA.
Zhongjie Wang, Wenhan Huang, Feifeng Ren, Lei Luo, Jun Zhou, Dongmei Huang, Mei Jiang, Huaan Du, Jinqi Fan, Lin Tang   +9 more
doaj   +1 more source

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Frontiers in Pharmacology, 2020
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members ...
Natalia L. Rukavina Mikusic, Mauro G. Silva, Angélica M. Pineda, Mariela M. Gironacci   +3 more
doaj   +1 more source

Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2011
Introduction: A new arm of the renin–angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells.
BERNARDI, STELLA, ZENNARO, CRISTINA, PALMISANO, SILVIA, Velkoska E., SABATO, NICOLETTA, TOFFOLI, BARBARA, GIACOMEL, GRETA, Buri L., ZANCONATI, FABRIZIO, Bellini G., Burrell L.M., de Manzini, Nicolo', FABRIS, BRUNO   +12 more
openaire   +4 more sources

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands. [PDF]

PLoS ONE, 2014
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS.
Kalyan C Tirupula, Russell Desnoyer, Robert C Speth, Sadashiva S Karnik   +3 more
doaj   +1 more source