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Angiotensin II type 2 receptor-interacting protein prevents vascular senescence
Journal of the American Society of Hypertension, 2012Angiotensin II type 2 (AT(2)) receptor-interacting protein (ATIP), which interacts with the C-terminal tail of the AT(2) receptor, regulates the functions of the AT(2) receptor. We have reported that AT(2) receptor stimulation attenuated vascular senescence. Therefore, we examined the possible negative role of ATIP in regulating vascular senescence. We
Li-Juan, Min +6 more
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[Angiotensin II type 1 and type 2 receptor].
Nihon rinsho. Japanese journal of clinical medicine, 2009The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
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Angiotensin II type 2 receptor effect on microvascular hydraulic permeability
Journal of Surgical Research, 2004Angiotensin II (Ang II) is a potent vasoconstrictor that modulates microvascular permeability. Angiotensin II type 1 (AT1) and type 2 (AT2) receptors have been described with subsequent development of their respective antagonists. We hypothesized that the AT2 receptor modulates microvascular permeability.Hydraulic permeability (L(p)) was measured in ...
Christopher R, Newton +2 more
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Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy
Hypertension, 1996We compared the ability of angiotensin II (Ang II) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. Over 72 hours, Ang II (1 μmol/L) increased the ratio of protein to DNA by less than 10%, whereas endothelin-1 (100 nmol/L) produced a 28% increase.
G W, Booz, K M, Baker
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Type-1 and type-2 angiotensin II receptors in fetal rat brain
European Journal of Pharmacology, 1991Brain angiotensin II receptors were located in 18-day-old rat embryos by quantitative autoradiography. In the nucleus of the solitary tract and choroid plexus, binding was displaced by the type-1 antagonist DuP 753. In the inferior olive, paratrigeminal and hypoglossal nuclei, binding was displaced by the type-2 antagonist CGP 42112 A.
K, Tsutsumi +3 more
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Angiotensin II Type 2 Receptor (AT2R) in Glomerulogenesis
2019Les données épidémiologiques indiquent que le diabète maternel est associé de manière significative aux anomalies congénitales des reins et des voies urinaires (CAKUT), ce qui implique un risque accru de CAKUT chez la progéniture des mères diabétiques par rapport à la population globale.
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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
Nature, 1995T. Ichiki +9 more
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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
Nature, 1995L. Hein +4 more
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Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nature Structural & Molecular Biology, 2018H. Asada +13 more
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