Results 1 to 10 of about 200,741 (145)
Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]
Kidney Research and Clinical Practice, 2023 Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha +3 more
doaj +1 more source
Biomedical Papers, 2022 Aims. Sub-analysis of a retrospective nation-wide observational analysis of heart failure (HF) epidemiology reported to the Czech National Registry of Reimbursed Health Services between 2012 and 2018 aimed at angiotensin-converting enzyme inhibitors ...
Renata Aiglova +10 more
doaj +1 more source
Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate renal dysfunction and fibrosis through ...
Majid Askaripour +9 more
doaj +1 more source
Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19
Biomolecules, 2021 Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the presence ...
Graham J. Moore +6 more
doaj +1 more source
Nepalese Medical Journal, 2020 Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in ...
Kunal Bikram Shaha +5 more
doaj +1 more source
Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Molecular Medicine, 2020 Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
doaj +1 more source
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients
eLife, 2020 The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi +2 more
doaj +1 more source
Biomedicines, 2022 Recent studies have shown that fascial fibroblasts are sensitive to different stimuli (biochemical or biophysical), promoting extracellular matrix remodeling, as well as synthetic activity.
Carmelo Pirri +8 more
doaj +1 more source
Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6 [PDF]
CHIN.PHYS.LETT. Vol.38, No.1(2021)018701 Express Letter, 2021 The spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health crisis. The binding affinity of SARS-CoV-2 (in particular the receptor binding domain, RBD) to its receptor angiotensin converting enzyme 2 (ACE2) and the antibodies is of great importance in ...
arxiv +1 more source
Current and future use of angiotensin II receptor blockers in patients with COVID-19
Качественная клиническая практика, 2020 No scientific evidence for the negative influence of angiotensin II receptor blockers onto COVID-19 clinical course has been identified so far. Prescribing angiotensin II receptor blockers as COVID-19 pathogenetic therapy could only be considered within ...
A. V. Matveev +2 more
doaj +1 more source