Results 91 to 100 of about 2,636,203 (317)

Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Angiotensin II type 1 receptor (AT1R) autoantibody (AT1‐AA) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II), AT1‐AA can induce vasoconstriction in a sustained manner, causing a ...
Jingwei Bian, Jinghui Lei, Xiaochen Yin, Pengli Wang, Ye Wu, Xiaoli Yang, Li Wang, Suli Zhang, Huirong Liu, Michael L. X. Fu   +9 more
doaj   +1 more source

Angiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink

British Journal of Clinical Pharmacology, 2015
Aims This was a cohort study to evaluate whether individuals exposed to angiotensin receptor blockers have a reduced risk of dementia compared with those exposed to angiotensin-converting enzyme inhibitors.
K. L. Goh, K. Bhaskaran, C. Minassian, S. Evans, L. Smeeth, I. Douglas   +5 more
semanticscholar   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Use of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Geriatric Ischemic Stroke Patients: Are the Rates Right?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundOur objective is to estimate the effects associated with higher rates of renin‐angiotensin system antagonists, angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers (ACEI/ARBs), in secondary prevention for geriatric (aged ...
John M. Brooks, Cole G. Chapman, Manish Suneja, Mary C. Schroeder, Michelle A. Fravel, Kathleen M. Schneider, June Wilwert, Yi‐Jhen Li, Elizabeth A. Chrischilles, Douglas W. Brenton, Marian Brenton, Jennifer Robinson   +11 more
doaj   +1 more source

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

New England Journal of Medicine, 2019
BACKGROUND The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction.
S. Solomon, J. McMurray, I. Anand, J. Ge, C. Lam, A. Maggioni, F. Martinez, M. Packer, M. Pfeffer, B. Pieske, M. Redfield, J. Rouleau, D. V. van Veldhuisen, F. Zannad, M. Zile, Akshay S. Desai, Brian Claggett, P. Jhund, S. Boytsov, J. Comín-Colet, J. Cleland, H. Düngen, E. Goncalvesova, T. Katova, J. K. Kerr Saraiva, M. Lelonek, B. Merkely, M. Senni, Sanjiv J. Shah, Jingmin Zhou, A. Rizkala, J. Gong, V. Shi, M. Lefkowitz   +33 more
semanticscholar   +1 more source

Animal models of hypertension and concurrent organs injury

Animal Models and Experimental Medicine, EarlyView.
Although hypertension is a frequently seen chronic condition across the world, its exact cause remains unclear. Animal models are beneficial for clarifying the pathogenic mechanism of hypertension and examining new treatments. An optimal animal model for studies on hypertension must well mimic human‐like hemodynamics and pathophysiological structural ...
Ye Wang, Xiaoliang Jiang, Zhiwei Yang
wiley   +1 more source

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID‐19 and future pandemic threats?

Animal Models and Experimental Medicine, EarlyView.
In this review, the pathological, molecular, and cellular changes observed in the COVID‐19 lung are compared to those in the laboratory rat treated with monocrotaline (MCT). Similarities that reflect common changes associated with inflammation and endothelial cell dysfunction are observed in both states, leading to a lung pathology characterized by ...
Luke P. Kris, Dani‐Louise Dixon, Shailesh Bihari, Jillian M. Carr   +3 more
wiley   +1 more source

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches

Animal Models and Experimental Medicine, EarlyView.
Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Wen‐Bing Ma, Rong‐Hua Yin, Guang‐Ming Ren, Yin Zhang, Li‐Juan Li, Wei Liu, Ting Chen, Wei Zhou, Mian Zu, Rong‐Ling Yin, Xin‐Di Shi, Lei Wang, Xiao‐Ming Yang   +12 more
wiley   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Angiotensin II AT ₁ Receptor Antagonists Inhibit Platelet Adhesion and Aggregation by Nitric Oxide Release [PDF]

, 2002
Leszek Kalinowski, Tomasz Matys, Ewa Chabielska, Włodzimierz Buczko, Tadeusz Maliñski   +4 more
openalex   +1 more source