Results 121 to 130 of about 2,636,203 (317)
Chemically Synthesized LRAD3‐D1 Interacts with N‐Terminal Domain of SARS‐CoV‐2 Spike Protein
ChemBioChem, EarlyView.Chemical synthesis, calcium‐templated in‐vitro folding and competitive ELISA assay reveal that only domain 1 of the LRAD3 ectodomain interacts with the severe acute respiratory syndrome‐related corona virus 2 (SARS‐CoV‐2) spike NTD, while domains 2 and 3 do not, providing valuable insight into ACE2‐independent viral entry pathways that may contribute ...
Mrinmoy Jana +5 more
wiley +1 more source
Method Overview for Discovering ATE1 Substrates and their Arginylation Sites
ChemBioChem, EarlyView.Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss +2 more
wiley +1 more source
Effect of Angiotensin Receptor Blocker and Probiotics in Caffeine-Induced Anxiety Model
, 2022 Pooja Verma, Siraj Anwar
openalex +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The quality of saphenous vein (SV) grafts can vary depending on the site from which they are harvested. However, few studies have compared SV grafts harvested from the thigh with those harvested from the calf to explore which is more appropriate for use in coronary artery bypass grafting (CABG). In this study, we evaluated the graft
Aidong Chen, Ke Pan
wiley +1 more source
Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid
ChemistryEurope, EarlyView.Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai +11 more
wiley +1 more source
Practical Recommendations for the Use of Angiotensin Receptor-Neprilysin Inhibitors (ARNI) in Heart Failure: Insights from Indian Cardiologists [PDF]
, 2023 Jamshed Dalal +10 more
openalex +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, EarlyView.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu +21 more
wiley +1 more source