Results 31 to 40 of about 200,791 (194)

Is Covid-19 severity associated with ACE2 degradation? [PDF]

arXiv, 2021
Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid.
arxiv  

Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT2R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats ...
Brandon A. Kemp, Nancy L. Howell, Susanna R. Keller, John J. Gildea, Weijian Shao, Luis Gabriel Navar, Robert M. Carey   +6 more
doaj   +1 more source

Angiotensin-(1–7) attenuates SARS-CoV2 spike protein-induced interleukin-6 and interleukin-8 production in alveolar epithelial cells through activation of Mas receptor

Journal of Microbiology, Immunology and Infection, 2023
Background: SARS-CoV-2 spike proteins (SP) can bind to the human angiotensin-converting enzyme 2 (ACE2) in human pulmonary alveolar epithelial cells (HPAEpiC) and trigger an inflammatory process.
Yi-Luen Shen, Yi-An Hsieh, Po-Wei Hu, Po-Chun Lo, Yi-Han Hsiao, Hsin-Kuo Ko, Fang-Chi Lin, Chien-Wen Huang, Kang-Cheng Su, Diahn-Warng Perng   +9 more
doaj  

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Deposition distribution of the new coronavirus (SARS-CoV-2) in the human airways upon exposure to cough-generated aerosol [PDF]

Scientific Reports 2020, 10, 22430, 2020
The new coronavirus disease 2019 (COVID-19) has been emerged as a rapidly spreading pandemic. The disease is thought to spread mainly from person-to-person through respiratory droplets produced when an infected person coughs, sneezes, or talks. The pathogen of COVID-19 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv   +1 more source

Evaluation of prescription pattern of anti - Hypertensive drugs in Urban population of Hyderabad

MRIMS Journal of Health Sciences, 2014
Knowledge of existing prescription patterns in the treatment of hypertension can provide useful information for improving clinical practice in this field.
M Jamuna Rani, G Jyothsna, Rohit Singh
doaj   +1 more source

Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model

PPAR Research, 2020
The activation of the renin-angiotensin system (RAS) participates in the development of metabolic syndrome (MetS) and in heart failure. PPAR-alpha activation by fenofibrate reverts some of the effects caused by these pathologies.
María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz   +7 more
doaj   +1 more source

SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker [PDF]

arXiv, 2020
Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged.
arxiv  

Next Step in Chronic Kidney Disease Therapy

Počki, 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous ...
D.D. Ivanov
doaj   +1 more source

Featuring ACE2 binding SARS-CoV and SARS-CoV-2 through a conserved evolutionary pattern of amino acid residues [PDF]

arXiv, 2020
Spike (S) glycoproteins mediate the coronavirus entry into the host cell. The S1 subunit of S-proteins contains the receptor-binding domain (RBD) that is able to recognize different host receptors, highlighting its remarkable capacity to adapt to their hosts along the viral evolution.
arxiv