Journal of Pharmacological Sciences, 2009 The present study investigated the internalization behavior of the constitutively active mutant (CAM) N111G of angiotensin II type 1 (AT1) receptor and correlated the result with the mechanism of the constitutive activity of the mutant.
Mohiuddin Ahmed Bhuiyan +5 more
doaj
Arterial hypertension and coronary heart disease: the place of angiotensin II receptor antagonists
Кардиоваскулярная терапия и профилактика, 2012 The paper considers arterial hypertension and coronary heart disease as pathologies which share multiple pathogenetic mechanisms. The role of angiotensin II receptor antagonists (ARA) in the effective treatment of these diseases and in prevention of ...
E. O. Taratukhin
doaj +1 more source
Use of angiotensin II receptor blockers in children- a review of evidence [PDF]
, 2015 Background: The incidence of hypertension in the pediatric population has been increasing. Childhood blood pressure is predictive of adult BP. The renin angiotensin aldosterone system pathway is important in the mediation of pediatric hypertension.
Amao, O, Nwaiwu, O, Olayemi, SO
core +2 more sources
Drug Testing and Analysis, EarlyView.Regarding cardiovascular effects, DMH decreased vascular reactivity to phenylephrine and acetylcholine. We observed that the combination of DPH and 8‐Cl‐T was identified as the responsible for increasing blood pressure and heart rate in the biological model used.
Jazmín Flores‐Monroy +3 more
wiley +1 more source
Spectrofluorimetric method for determination of some angiotensin II receptor antagonists
Journal of Pharmaceutical Analysis, 2012 A simple, rapid, accurate and highly sensitive spectrofluorimetric method has been developed for determination of some angiotensin II receptor antagonists (AIIRA's), namely Losartan potassium (Los-K), Irbesartan (Irb), Valsartan (Val) and Candesartan ...
Salwa R. El-Shaboury +3 more
doaj
Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF [PDF]
, 2017 Aims: Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders.
Chen, Chen-Huan +16 more
core +3 more sources
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan [PDF]
, 1992 Hiroshi Azuma +2 more
openalex +1 more source
Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction
ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu +3 more
wiley +1 more source
Inhibition of the haemodynamic effects of angiotensin II in conscious rats by AT2‐receptor antagonists given after the AT1‐receptor antagonist, EXP 3174 [PDF]
, 1992 Robert E. Widdop +3 more
openalex +1 more source