Results 221 to 230 of about 444,347 (295)
Some of the next articles are maybe not open access.
Angiotensin receptor antagonists
2014Abstract The renin–angiotensin–aldosterone system (RAAS) is activated in patients with heart failure and contributes to many of the detrimental effects seen in these patients. Antagonists to the angiotensin II type-1 (AT1)-receptor (ARBs) provide a pharmacologically different mechanism of inhibiting the RAAS to ACE inhibitors.
Roy S. Gardner +2 more
openaire +2 more sources
Nonpeptide angiotensin II receptor antagonists
Trends in Pharmacological Sciences, 1991Substantial progress has been made recently in the development of nonpeptide angiotensin II receptor antagonists, a goal that has long remained an unmet challenge. Pieter Timmermans and colleagues review the pharmacology and the course of events that led to the identification of the lead compound and clinical candidate DuP753. Nonpeptide angiotensin II
P B, Timmermans +3 more
openaire +3 more sources
Angiotensin II receptors and angiotensin II receptor antagonists.
Pharmacological Reviews, 1993P B, Timmermans +9 more
openaire +3 more sources
Angiotensin receptor antagonists/hydrochlorothiazide
Reactions Weekly, 2013openaire +2 more sources
Angiotensin II receptor antagonists
The Lancet, 2000Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors.
M, Burnier, H R, Brunner
openaire +4 more sources
Angiotensin receptor antagonists: focus on losartan
The Lancet, 1995C. I. Johnston
openaire +3 more sources
Angiotensin Receptors and Their Antagonists
New England Journal of Medicine, 1996Angiotensins are peptide hormones derived from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes (Figure 1). The classic pathway of angiotensin synthesis includes a reaction catalyzed by angiotensin-converting enzyme (ACE), which occurs not only in plasma but also in the kidneys, brain, adrenal glands, ovaries, and ...
T L, Goodfriend, M E, Elliott, K J, Catt
openaire +2 more sources