Results 31 to 40 of about 358,234 (380)
Long-Term Consequences of Fetal Angiotensin II Receptor Antagonist Exposure
Case Reports in Pediatrics, 2018 Fetal angiotensin II receptor antagonist exposure is associated with major complications and even death when administered during pregnancy. Neonates frequently require intensive care treatment, and mortality is high.
K. Wegleiter +4 more
doaj +1 more source
CARDIAC GLYCOSIDES IN UP-TO-DATE CLINICAL PRACTICE
Alʹmanah Kliničeskoj Mediciny, 2016 The article reviews the use of cardiac glycosides in patients with chronic heart failure, paroxysmal tachyarrhythmia and chronic atrial fibrillation (rate control).
M. A. Gurevich, A. A. Gavrilin
doaj +1 more source
Predicting progression of aortic stenosis by measuring serum calcification propensity
Clinical Cardiology, Volume 45, Issue 12, Page 1297-1302, December 2022., 2022 Abstract Background The aim of this prospective, double‐blinded study in patients with aortic sclerosis was to determine whether a new calcification propensity measure in the serum could predict disease progression. Methods We included 129 consecutive patients with aortic sclerosis as assessed during a routine clinical echocardiographic exam. Clinical,
Reto Kurmann +4 more
wiley +1 more source
Journal of Biological Chemistry, 1995 To identify specific interactions between either the tetrazole or carboxylate pharmacophores of non-peptide antagonists and the rat AT1 receptor, 6 basic residues were examined by site-directed mutagenesis.
Keita Noda +6 more
semanticscholar +1 more source
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]
arXiv, 2022 Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv
Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats.
HYPERTENSION, 1998 Angiotensin II (Ang II) appears to exert its contractile and growth-promoting effects through the AT1 receptor subtype, whereas the AT2 subtype may have growth-inhibitory and proapoptotic properties.
Jin S. Li, R. Touyz, E. Schiffrin
semanticscholar +1 more source
Anatolian Journal of Cardiology, 2023 Background: The risk of cardiovascular disease is correlated with the frequency and control of associated risk factors in diabetes mellitus and may vary according to country.
Aytekin Oğuz +10 more
doaj +1 more source
Is Covid-19 severity associated with ACE2 degradation? [PDF]
arXiv, 2021 Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid.
arxiv
Angiotensin II Receptor Antagonists and Hypertension
Clinical and Experimental Hypertension, 1999 Over recent years, a number of imidazole derivatives that specifically bind to the angiotensin II type 1 receptor, thereafter called sartans, have been developed and made available to the clinician. Whether targeting antihypertensive treatment with such a high specificity within the renin cascade may carry major clinical advantage over inhibiting ...
Jean Ribstein +2 more
openaire +2 more sources