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Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
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Next Step in Chronic Kidney Disease Therapy
Počki, 2016 Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous ...
D.D. Ivanov
doaj +1 more source
Case Reports in Nephrology, 2020 The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna +7 more
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Neuroprotective Effects of Angiotensin Receptor Blockers [PDF]
American Journal of Hypertension, 2014 Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used compounds therapeutically effective in cardiovascular disorders, renal disease, the metabolic syndrome, and diabetes. It has been more recently recognized that ARBs are neuroprotective and have potential therapeutic use in many brain disorders.
Sonia, Villapol, Juan M, Saavedra
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Journal of Pharmacological Sciences, 2010 The role of angiotensin II in mediating hypertension and renal diseases is well documented, and inhibition of the renin–angiotensin–aldosterone system elicits antihypertensive and renoprotective effects.
Akira Nishiyama +3 more
doaj +1 more source
Renin-Angiotensin System Blockers and Renal Functional Reserve. Is There a Limit of Renoprotection?
Počki, 2015 Renin-angiotensin system (RAS) blockers (angiotensin converting enzyme inhibitors, angiotensin receptor blockers, direct renin inhibitor) have a renoprotective effect in the presence of preserved glomerular filtration rate in patients with chronic kidney
D.D. Ivanov
doaj +1 more source
Next generation multifunctional angiotensin receptor blockers [PDF]
Hypertension Research, 2009 Angiotensin receptor blockers (ARBs) are well-tolerated drugs that are known to be useful for inhibiting activity of the renin-angiotensin (RAS) system, treating hypertension and reducing the risk for cardiovascular disease. However, inhibition of the RAS does not control all pathophysiological mechanisms of hypertension or cardiovascular risk and many
Theodore W, Kurtz, Uwe, Klein
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Angiotensin receptor blockers and risk of dementia: cohort study in UK Clinical Practice Research Datalink. [PDF]
, 2014 AIMS: This was a cohort study to evaluate whether individuals exposed to angiotensin receptor blockers have a reduced risk of dementia compared with those exposed to angiotensin-converting enzyme inhibitors.
Bhaskaran, Krishnan +5 more
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Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies [PDF]
, 2016 Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are
Carlson, MC +4 more
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Angiotensin receptor blockers for heart failure [PDF]
Cochrane Database of Systematic Reviews, 2012 Chronic heart failure (HF) is a prevalent world-wide. Angiotensin receptor blockers (ARBs) are widely prescribed for chronic HF although their role is controversial.To assess the benefit and harm of ARBs compared with ACE inhibitors (ACEIs) or placebo on mortality, morbidity and withdrawals due to adverse effects in patients with symptomatic HF and ...
Balraj S, Heran +4 more
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