TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2
Advanced Science, EarlyView.This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao +12 more
wiley +1 more source
Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumors.
Folia Histochemica et Cytobiologica, 2008 Angiotensin II is well known to affect the adrenal cell growth and function. Angiotensin receptors AT1 and AT2 were found to be present in the normal adrenal gland.
Marek Pawlikowski +2 more
doaj +1 more source
Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]
, 2015 Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core +2 more sources
Annals of Gastroenterological Surgery, EarlyView.This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen +6 more
wiley +1 more source
Frontiers in Pharmacology, 2015 Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7 ...
Daniel eClayton +6 more
doaj +1 more source
Structural insights into ligand recognition and activation of angiotensin receptors. [PDF]
Trends Pharmacol Sci, 2021 Zhang H +5 more
europepmc +1 more source
Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention
Animal Models and Experimental Medicine, EarlyView.This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie +4 more
wiley +1 more source
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34. [PDF]
Br J Pharmacol, 2022 Singh KD, Karnik SS.
europepmc +1 more source
Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
core +1 more source
Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease
Arthritis &Rheumatology, EarlyView.Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman +2 more
wiley +1 more source