Results 31 to 40 of about 144,046 (306)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

[Review of] Sarah Blacher Cohen, ed. From Hester Street to Hollywood: The Jewish-American Stage and Screen [PDF]

, 1988
The considerable Jewish American presence on the stage and screen (and now television), has long been marveled at and discussed. Jewish dominance in mass media has been a source of pride to Jews and anguish to anti-semites.
Mayo, Louise
core   +1 more source

Implementation of Heidegger’s Angst into Buddhist Problem of Suffering: On How Buddhist Discourse Engenders and Epistemological Problem and How to Approach to it with Western Ontology

Revista Científica Arbitrada de la Fundación MenteClara, 2019
Early Buddhist discourse recognizes the problem of dukkha (suffering) and argues that the cause of dukkha can be removed. This paper attempts to demonstrate how Buddhist claim that dukkha can be removed fails as it creates epistemological complications ...
Ege Kaan Duman
doaj   +1 more source

Terrorism and the Constitutional Order [PDF]

, 2006
We panicked the last time terrorists struck, and we will panic the next time. September 11 was merely a pinprick compared to the devastation of a suitcase A-bomb or an anthrax epidemic.
Ackerman, Bruce
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

O AFETO NA PSICANÁLISE E AS DIFICULDADES DE SUA OPERACIONALIZAÇÃO

Affectio Societatis, 2014
This paper, from the theoretical developments that the term affection (and its surrogate, anguish) had in Freud’s work, tries to establish the character of impossibility of the field to which it refers along with the subjective consequences that may ...
Oswaldo França Neto
doaj  

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

O existencialismo em Pascal Pascal's existentialism

Trans/Form/Ação, 2003
O homem traz inscrito no mais profundo do seu ser "a marca do nada", "o traço vazio". Porque traz esse vazio, ele tudo faz para preenchê-lo. Cria "eus imaginários" formando-os com as qualidades que estima e que os outros também estimam; tenta impô-los ...
Ivonil Parraz
doaj   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source