Results 41 to 50 of about 11,105 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Studia Humanitatis, 2016 The article describes the basic trends of social and status changes occurring under the influence of the process referred to as “pain distribution”. Traditional culture included a number of constraints designed to reduce aggressive tendencies in the ...
Pulkin Maxim Viktorovich
doaj
Tracés, 2020 Anguish: The Case History of a Dying Trajectory (1970) is an exemplification of the grounded theory approach already developed by the sociologists Anselm Strauss and Barney Glaser in Awareness of Dying (1965) and Time for Dying (1968).
Anthony Stavrianakis, Laurence Tessier
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Child and Adolescent Psychological Distress Scale (EDISTRESS-IJ): Proposal for a Reduced Assessment Instrument [PDF]
Paidéia (Ribeirão Preto): Distress is an important component that must be considered in students’ mental health. The general objective of this study was to propose the investigation of a model composed of items from different instruments that assess elements of distress and ...
Makilim Nunes Baptista +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
O AFETO NA PSICANÁLISE E AS DIFICULDADES DE SUA OPERACIONALIZAÇÃO
Affectio Societatis, 2014 This paper, from the theoretical developments that the term affection (and its surrogate, anguish) had in Freud’s work, tries to establish the character of impossibility of the field to which it refers along with the subjective consequences that may ...
Oswaldo França Neto
doaj
Freedom, Anguish and Bad Faith in Mr. Nobody: Sartrean Existentialism in Cinema
Film-PhilosophyThis article explores how the film Mr. Nobody (2009), directed by Jaco Van Dormael, illustrates key concepts of Sartrean existentialism. The film exemplifies an existential condition through the character of Nemo Nobody (Jared Leto), whose life unfolds ...
Thaís de Sá Oliveira
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source