Brazilian Journal of Medical and Biological Research, 2001 Hydrolysis of D-valyl-L-leucyl-L-arginine p-nitroanilide (7.5-90.0 µM) by human tissue kallikrein (hK1) (4.58-5.27 nM) at pH 9.0 and 37ºC was studied in the absence and in the presence of increasing concentrations of 4-aminobenzamidine (96-576 µM ...
M.O. Sousa +5 more
doaj +1 more source
A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time
Advanced Science, EarlyView.This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li +15 more
wiley +1 more source
Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics
Advanced Science, EarlyView.The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu +4 more
wiley +1 more source
Synthesis Of New Asymmetrical Pyromellitdiimides Derived From Pyromellitic Dianhydride
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 This work involves the synthesis and characterization of asymmetrical pyromellitdiimide derivatives [IV]a-f by four sequence steps selective reaction . One mole of pyromellitic dianhydride was reacted with one mole of various primary aromatic amines [
E. T. Ali
doaj
A multimedia activity model for ionizable compounds: Validation study with 2,4-dichlorophenoxyacetic acid, aniline, and trimethoprim [PDF]
, 2009 Antonio Franco, Stefan Trapp
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Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. [PDF]
, 2009 Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders.
BÜHRING U +8 more
core +1 more source
Nanozyme‐Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy
Advanced Science, EarlyView.A nanozyme–integrated hydrogel (PTC‐MP) exhibiting with mild photothermal effects is constructed, and a “3R” (restrain‐restore‐reinforce) strategy is proposed for diabetic osteoarthritis (DOA) treatment based on advanced glycation end products (AGEs) targeting.
Rui Chen +8 more
wiley +1 more source
Photochemische Addition von Anilinen an 1,3-Diene
CHIMIA, 1979 Anilines, e. g. aniline (12), N-methylaniline (16), 2,6-dimethyl-aniline (14), 2-(2'-butenyl)-N-methylaniline (4) or 2-(2'-cyclo-hexenyl)-N-methylaniline (8) when irradiated with a high pressure mercury lamp in methanol, acetonitrile, benzene or ...
Synèse Jolidon, Hans-Jürgen Hansen
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Ag2CO3 Mediated Oxidative Dehydrogenative Coupling of Anilines Giving Aromatic Azo Compounds [PDF]
, 2017 Yulong An +2 more
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Advanced Science, EarlyView.In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li +8 more
wiley +1 more source