Results 141 to 150 of about 71,027 (286)

Synthesis and Characterization of π‐Extended Azulenes via Nucleophilic Substitution and Intramolecular Cyclization of 5‐Alkynyl‐6‐Fluoroazulenes

ChemistryEurope, EarlyView.
A modular synthetic approach enables the preparation of azulene‐fused heterocycles via nucleophilic aromatic substitution followed by intramolecular cyclization of alkynyl fluoroazulenes. The method allows the incorporation of various heteroatoms (N, O, S, Se, and Te), leading to structurally diverse heteroannulated azulenes.
Martin C. Dietl, Matthias Scherr, Christopher Hüßler, Henrik T. Habeck, Carmen L. M. Henel, Jürgen Graf, Frank Rominger, Matthias Rudolph, A. Stephen K. Hashmi   +8 more
wiley   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization

ChemistryEurope, EarlyView.
A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo, Jing Dai, Yongchang Wei, Chang Min   +3 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, EarlyView.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source

Porphyrin‐Geländer–Helical Conjugated Banister Type Porphyrin Dyads

Chemistry – A European Journal, EarlyView.
Porphyrin arrays go chiral–A porphyrin Geländer macrocycle represents the intriguing prototype architecture of helically chiral butadiyne‐linked porphyrin arrays. This study combines synthetic, spectroscopic, and computational methods to shed light on its structure, chiroptical properties, and tunability, highlighting its promise for advancing ...
Joël F. Keller, Adriano D'Addio, Marcel Mayor   +2 more
wiley   +1 more source

Switching between photochromism and photoluminescence in Schiff base derivatives by molecular design of end groups. [PDF]

Chem Sci
Zhang Q, Zhou X, Shan X, He F, Bao Y, Xu H, Zhu C, Zhu B.   +7 more
europepmc   +1 more source

Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine

Chemistry – A European Journal, EarlyView.
Photochemical activation of N‐phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. Spectroscopic and kinetic analyses identify a key vanadium(IV)‐hydroxylamine intermediate, elucidate the crucial roles of the acidic medium, the ...
Dana Králová, Maximilian Philipp, Matthias Schmalzbauer, Thilo Reiter, Bernd Schäfer, Ruth M. Gschwind, Burkhard König   +6 more
wiley   +1 more source

Synthesis, biological evaluation, molecular docking, molecular dynamics simulation, and ADME studies of novel carbazole-aniline hybrids as cytotoxic agents. [PDF]

BMC Chem
Moradimehrabadi M, Khabnadideh S, Emami L, Mostashfi H, Khajehpour N, Firozbakhsh M, Sadeghian S, Rezaei Z.   +7 more
europepmc   +1 more source