Results 71 to 80 of about 4,395,835 (285)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A comparison of equine-assisted intervention and conventional play-based early intervention for mother-child dyads with insecure attachment

, 2015
Early interventions aim at promoting a good mother–child relationship as basis for a good socio-emotional development, especially in high-risk populations, and at correcting already unfavorable patterns of interaction and are common today.
Uvnäs-Moberg, Kerstin,, Sveriges lantbruksuniversitet., Kotrschal, Kurt,, Julius, Henri,, Beetz, Andrea,, Winkler, Nora,, Uvnäs-Moberg, Kerstin   +6 more
core   +1 more source

Animal-assisted therapy, including animal-assisted activities and resident animals, for improving quality of life in people with stroke [PDF]

, 2019
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of animal‐assisted therapy for improving quality of life for people with stroke.
Hawkins, Roxanne; id_orcid, Hawkins, Emma, Dennis, Martin, Lawrie, Stephen M, Williams, Joanne; id_orcid   +4 more
core   +1 more source

Chapter 7: Animal-Assisted Intervention and Professional Practice

Title - Chapter 7: Animal-Assisted Intervention and Professional Practice Description of content: This chapter provides an overview of different types of animal-assisted interventions and their definitions, their history and purpose.
Mirena Dimolareva (17467341), Kerstin Meints (17163367), Victoria Brelsford (17154487)   +2 more
core   +2 more sources

Can the treatment effects of human-animal interaction be maintained? A randomized controlled trial including follow-up in people with severe mental illness

Frontiers in Psychiatry
IntroductionThere are persistent demands for well-designed randomized controlled trials (RCTs), including follow-up measurements, in studies on animal-assisted treatment (AAT). In addition, a possible dose-response relationship is under discussion.
Petra Schmid, Petra Schmid, Stefan Tschöke, Stefan Tschöke, Carmen Nauss, Petra Prinz, Claudia Jauch-Ederer, Anna Lena Kordeuter, Carmen Uhlmann, Carmen Uhlmann   +9 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The human–animal bond and animal-assisted intervention

, 2018
Animal-assisted interventions (AAI) are increasing in mental and physical healthcare and education. These interventions include a range of structures and objectives. AAI is the umbrella term that includes the practice of animal-assisted therapy (AAT) and
Shawna J. Weaver, Aubrey H. Fine
core   +1 more source

Animal assisted interventions

, 2021
Psychosocial interventions are essential to support people with dementia. This guide is intended for all professionals working directly or indirectly with people with dementia. It aims to improve knowledge, understanding and implementation of psychosocial interventions that can be provided to them.
openaire   +2 more sources

Animal-Assisted Therapy in Mental Illness [PDF]

, 2023
Mental health disorders are a significant global health concern, with a growing need for alternative therapeutic approaches. Animal-assisted therapy has gained recognition for its potential to improve the emotional and psychological well-being of ...
Cypress, Chanae
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source