Results 111 to 120 of about 597,981 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Bark consumption of creosote bush (Larrea cuneifolia) by cuises (Microcavia australis): effect on branch survival and reproduction

open access: yesEcología Austral, 2006
Locally, mammalian herbivores may have significant effects on the abundance and fitness of plant species. This study focuses on the interaction between cuises (Microcavia australis –Rodentia-) and creosote bush (Larrea cuneifolia –Zygophyllacea-), which
Claudia M. Campos   +4 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recognize the Little Ones: UAS-Based In-Situ Fluorescent Tracer Detection

open access: yesDrones, 2019
In ecological research, a key interest is to explore movement patterns of individual organisms across different spatial scales as one driver of biotic interactions.
Henning Teickner   +4 more
doaj   +1 more source

Industrial Grain Hemp Planting Date Trial [PDF]

open access: yes, 2017
Hemp is a non-psychoactive variety of cannabis sativa L. The crop is one of historical importance in the U.S. and reemerging in worldwide importance as manufacturers seek hemp as a renewable and sustainable resource for a wide variety of consumer and ...
Cummings, Erica   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Plant survival and keystone pollinator species in stochastic coextinction models: role of intrinsic dependence on animal-pollination

open access: yesScientific Reports, 2017
Coextinction models are useful to understand community robustness to species loss and resilience to disturbances. We simulated pollinator extinctions in pollination networks by using a hybrid model that combined a recently developed stochastic ...
Anna Traveset   +2 more
doaj   +1 more source

Agrobiodiversity and Its Conservation in Nepal [PDF]

open access: yes, 2020
Nepal is a part of the world\u27s biodiversity hotspot and ranks the 49th in the world for biodiversity. Agrobiodiversity and its conservation status were studied through literature review, field survey, key informant survey and focus group discussion ...
Ghimire, K. H. (Krishna)   +8 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Technology and Biological Weapons: Future Threats [PDF]

open access: yes, 2004
Ye
Davison, N., Millett, P., Nixdorff, K.
core  

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