Results 101 to 110 of about 597,981 (301)

Using the Pathogen-Host Interactions database (PHI-base) to investigate plant pathogen genomes and genes implicated in virulence

Frontiers in Plant Science, 2015
New pathogen-host interaction mechanisms can be revealed by integrating mutant phenotype data with genetic information. PHI-base is a multi-species manually curated database combining peer-reviewed published phenotype data from plant and animal pathogens
Martin eUrban, Alistair G Irvine, Alayne eCuzick, Kim E Hammond-Kosack   +3 more
doaj   +1 more source

Animal–plant interactions in a Middle Permian permineralised peat of the Bainmedart Coal Measures, Prince Charles Mountains, Antarctica

Palaeogeography, Palaeoclimatology, Palaeoecology, 2012
AbstractEvidence for invertebrate feeding on glossopterid gymnosperms is documented from Middle Permian silicified peats of the Prince Charles Mountains, Antarctica, in the form of coprolites occurring both free in the peat matrix and clustered within excavations in roots, aerial wood and leaves. Observations of coprolites in thin-sections of the peats
Slater, Ben J., McLoughlin, Stephen, Hilton, Jason   +2 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The interaction between dietary nitrates/nitrites intake and gut microbial metabolites on metabolic syndrome: a cross-sectional study

Frontiers in Public Health
BackgroundMetabolic syndrome (MetS) prevalence has increased globally.The evidence shows thatdiet and gut microbial metabolites includingtrimethylamine N-oxide (TMAO) and kynurenine (KYN) play an important role in developing MetS.
Atieh Mirzababaei, Maryam Mahmoodi, Abbasali Keshtkar, Sara Ebrahimi, Fereshteh Pashayee-Khamene, Faezeh Abaj, Mina Radmehr, Pardis Khalili, Mahya Mehri Hajmir, Khadijeh Mirzaei   +9 more
doaj   +1 more source

Characterization of ROP GTPase-activated Arabidopsis receptor-like cytoplasmic kinases (RLCK class VI_A) [PDF]

, 2011
Plants have to respond and adapt to a variety of continuously changing environmental factors in order to establish an appropriate developmental strategy to ensure survival. There are ample data showing that protein phosphorylation/dephosphorylation plays
Jurca Elena Manuela
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Quantifying the impacts of defaunation on natural forest regeneration in a global meta-analysis

Nature Communications, 2019
The defaunation of vertebrates may disrupt forest functioning through the loss of plant-animal interactions, but impacts on forests remain unquantified. Here the authors show that seed dispersal is a key interaction and defaunation of primates and birds ...
Charlie J. Gardner, Jake E. Bicknell, William Baldwin-Cantello, Matthew J. Struebig, Zoe G. Davies   +4 more
doaj   +1 more source

New record of a very specialized interaction: myrcidris epicharis Ward 1990 (Pseudomyrmecinae) and its myrmecophyte host Myrcia madida McVaugh (Myrtaceae) in Brazilian Meridional Amazon Novo registro de uma interação altamente especializada: myrcidris epicharis Ward 1990 (Pseudomyrmecinae) e sua mirmecófita hospedeira Myrcia madida McVaugh (Myrtaceae) na Amazônia Meridional brasileira

Acta Amazonica, 2012
In this study we present a new record of a plant-animal interaction: the mutualistic relationship between the specialist plant-ant Myrcidris epicharis Ward, 1990 (Pseudomyrmecinae) and its myrmecophyte host Myrcia madida McVaugh (Myrtaceae).
Ricardo Eduardo Vicente, Wesley Dáttilo, Thiago Junqueira Izzo   +2 more
doaj   +1 more source