Results 111 to 120 of about 14,780 (225)
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem, Volume 26, Issue 7, April 1, 2025.Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen +8 more
wiley +1 more source
The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question [PDF]
, 2017 Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two
Gettinby, George +2 more
core +1 more source
The FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley +1 more source
The vicious circle and infection intensity: The case of Trypanosoma microti in field vole populations [PDF]
, 2009 Objective: In natural populations, infection and condition may act synergistically to trigger a vicious circle: poor condition predisposes to host infections, which further reduce condition, and so on.
Begon, Michael +5 more
core +1 more source
The spatial ecology of free-ranging domestic pigs (Sus scrofa) in western Kenya [PDF]
, 2013 Background In many parts of the developing world, pigs are kept under low-input systems where they roam freely to scavenge food. These systems allow poor farmers the opportunity to enter into livestock keeping without large capital investments.
Cook, Elizabeth A. +3 more
core +3 more sources
Biological and pharmacological investigations of novel diamidines in animal models of human African trypanosomiasis [PDF]
, 2013 "African sleeping sickness, also called human African trypanosomiasis (HAT), results from the infection of humans with either of two protozoan parasites, Trypanosoma brucei gambiense and T. b. rhodesiense. HAT is transmitted by tsetse flies (Glossina spp) and, like the vector, is found exclusively in Africa between the latitudes 14° North and 29° South.
openaire +3 more sources
Resolving the apparent transmission paradox of African sleeping sickness.
PLoS Biology, 2019 Human African trypanosomiasis (HAT), or African sleeping sickness, is a fatal disease found throughout sub-Saharan Africa. The disease is close to elimination in many areas, although it was similarly close to elimination once before and subsequently ...
Paul Capewell +12 more
doaj +1 more source
The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]
, 2019 Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K. +2 more
core +2 more sources
Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle
Parasites & Vectors, 2017 Background Serological tests for gambiense human African trypanosomiasis (gHAT) detect antibodies to antigens on the cell surface of bloodstream trypanosomes.
Enock Matovu +5 more
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin +5 more
doaj