Results 131 to 140 of about 8,931,469 (334)

DIFFERENTIAL REINFORCEMENT OF ALTERNATIVE BEHAVIOR INCREASES RESISTANCE TO EXTINCTION: CLINICAL DEMONSTRATION, ANIMAL MODELING, AND CLINICAL TEST OF ONE SOLUTION [PDF]

, 2010
F. Charles Mace, Jennifer J. McComas, Benjamin C. Mauro, Patrick R. Progar, Bridget A. Taylor, Ruth A. Ervin, Amanda N. Zangrillo   +6 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Field Trial using Combined Treatment of Garlic and Organic Spray Formula for Flie’s Control and Animal Defensive Behavior Alleviation in Cattle Farm [PDF]

, 2016
Asmaa N. Mohamme, Naglaa M. Abdel A, Gehan K. Abdel L   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Linking neural circuits to the mechanics of animal behavior in Drosophila larval locomotion. [PDF]

Front Neural Circuits, 2023
Kohsaka H.
europepmc   +1 more source

WHY VETERINARIANS SHOULD UNDERSTAND ANIMAL BEHAVIOR

, 2018
Marijana Vučinić, Katarina Nenadović, Dunja KOVAČ, Ljiljana Janković   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clicker Training in Minipigs to Reduce Stress during Blood Collection—An Example of Applied Refinement

Animals
Pigs (and minipigs) are often restrained with a maxillary sling for blood collection. They mainly produce strong vocalisations and show resistance to the procedure, which subjectively appears to be stressful for the animals.
Delia Fiderer, Christa Thoene-Reineke, Mechthild Wiegard   +2 more
doaj   +1 more source

Chronotate: An open-source tool for manual timestamping and quantification of animal behavior. [PDF]

Neurosci Lett, 2023
Philipsberg PA, Christenson Wick Z, Diego KS, Vaughan N, Galas A, Jurkowski A, Feng Y, Vetere LM, Chen L, Soler I, Cai DJ, Shuman T.   +11 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source