Results 211 to 220 of about 2,222,991 (278)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Exploring the link between asprosin and glucose and lipid dysregulation in offspring of diabetic mothers in a rat model. [PDF]

PLoS One
Ahmadasadi H, Rasouli Emamgholi P, Layali I, Kianfar T, Tork S, Jafarpour M, Aliabadi M, Heydari H.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Reply to the Letter to the Editor: "Effects of rifaximin in fructose-induced steatohepatitis in rats". [PDF]

Hepatol Forum
Celik NC, Goc RY, Bahcecioglu IH, Ozercan IH, Tuzcu M, Ilhan N, Sahin K.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Phenolic-Rich <i>Aronia melanocarpa</i> (cv. Nero) Extract Attenuates Doxorubicin-Induced Nephrotoxicity Associated with Reduced Oxidative Stress, Inflammation, and Endoplasmic Reticulum Stress. [PDF]

Molecules
Malkoç MA, Yaman SÖ, Çınkılıç H, Yuluğ E, Kara Y, Kural B, Kolaylı S.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Alpha-synuclein and mitochondrial permeability transition pore interactions in rotenone-induced Parkinson's disease models: neuroprotective promise of cyclosporine A. [PDF]

Biochem Biophys Rep
Singh S, Bir A, Thakur R, Chauhan A, Ghosh A, Mittal A, Nayak AK, Chakrabarti SS, Chakrabarti S.   +8 more
europepmc   +1 more source

Sustained clinical remission and long-term safety of molnupiravir as first-line therapy for effusive feline infectious peritonitis: a 40-week retrospective study. [PDF]

Vet Anim Sci
Surakitkoson T, Channgam P, Sakcamduang W, Soonthornsit J, Osathanon R.   +4 more
europepmc   +1 more source

Correction: IGF-1 supplementation improves <i>in vitro</i> maturation quality of <i>Capra hircus</i> oocytes via PDE3A activation, gap junction remodeling, apoptosis suppression, and kisspeptin signaling. [PDF]

Front Vet Sci
Widjiati W, Luqman EM, Darsini N, Aulanni'am A, Hendrawan VF, Kurniawati DY, Jaafar WNFBW.   +6 more
europepmc   +1 more source