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Recent advances in exploring the composition and evolution of the prokaryotic selenoproteome [PDF]
Applied and Environmental MicrobiologySelenoproteins, a unique class of proteins critical for cellular antioxidant defense, are characterized by the incorporation of selenocysteine (Sec) in their active sites.
Yan Zhang +3 more
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The Role and Mechanism of Essential Selenoproteins for Homeostasis
Antioxidants, 2022 Selenium (Se) is one of the essential trace elements that plays a biological role in the body, mainly in the form of selenoproteins. Selenoproteins can be involved in the regulation of oxidative stress, endoplasmic reticulum (ER) stress, antioxidant ...
Yaoxing Chen +2 more
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Selenoproteins: Minute yet vital players governing cellular fate [PDF]
Genes and DiseasesSelenoproteins represent a distinct class of proteins that incorporate selenocysteine (Sec), whose biosynthesis and translational integration are dependent on selenium availability and the presence of a selenocysteine insertion sequence (SECIS).
Chaoyi Xia +5 more
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Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods [PDF]
BMC GenomicsSelenoproteins incorporate the rare selenium-containing amino acid selenocysteine (Sec) and play crucial roles for redox homeostasis, stress response, and hormone regulation. Sec is inserted by co-translational recoding of the UGA codon, normally a stop.
Max Ticó +2 more
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Antioxidants, 2019 Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in mice).
Qingyong Meng +2 more
exaly +3 more sources
Selenium, Selenoproteins, and Female Reproduction: A Review
Molecules, 2018 Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are ...
Christiana Angel +2 more
exaly +3 more sources
DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training [PDF]
Advanced ScienceSelenoproteins, defined as proteins containing the 21st amino acid, selenocysteine (Sec, U), are functionally important but rare, with only 25 selenoproteins characterized in the entire human proteome to date.
Chenfang Si +5 more
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Selenoprotein: Potential Player in Redox Regulation in Chlamydomonas reinhardtii
Antioxidants, 2022 Selenium (Se) is an essential micro-element for many organisms, including Chlamydomonas reinhardtii, and is required in trace amounts. It is obtained from the 21st amino acid selenocysteine (Sec, U), genetically encoded by the UGA codon.
Sandip A. Ghuge +2 more
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Frontiers in Neuroscience, 2021 Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang +4 more
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Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers
Biomolecules, 2022 A potential target of precision nutrition in cancer therapeutics is the micronutrient selenium (Se). Se is metabolized and incorporated as the amino acid selenocysteine (Sec) into 25 human selenoproteins, including glutathione peroxidases (GPXs) and ...
Briana K. Shimada +3 more
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