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The Role and Mechanism of Essential Selenoproteins for Homeostasis
Antioxidants, 2022 Selenium (Se) is one of the essential trace elements that plays a biological role in the body, mainly in the form of selenoproteins. Selenoproteins can be involved in the regulation of oxidative stress, endoplasmic reticulum (ER) stress, antioxidant ...
Jia-Qiang Huang, Zixu Wang, Yaoxing Chen
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Selenoproteins: Minute yet vital players governing cellular fate [PDF]
Genes and DiseasesSelenoproteins represent a distinct class of proteins that incorporate selenocysteine (Sec), whose biosynthesis and translational integration are dependent on selenium availability and the presence of a selenocysteine insertion sequence (SECIS).
Chaoyi Xia +5 more
doaj +2 more sources
Antioxidants, 2019 Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in mice).
Izhar Hyder Qazi +2 more
exaly +3 more sources
Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis. [PDF]
Adv Sci (Weinh)Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Zhang Y +11 more
europepmc +2 more sources
DeepSecMS Advances DIA‐Based Selenoproteome Profiling Through Cys‐to‐Sec Proxy Training [PDF]
Advanced ScienceSelenoproteins, defined as proteins containing the 21st amino acid, selenocysteine (Sec, U), are functionally important but rare, with only 25 selenoproteins characterized in the entire human proteome to date.
Chenfang Si +5 more
doaj +2 more sources
Selenium, Selenoproteins, and Female Reproduction: A Review
Molecules, 2018 Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are ...
Izhar Hyder Qazi +2 more
exaly +3 more sources
Selenium: A Key Element in Inflammatory Bowel Disease [PDF]
AntioxidantsInflammatory bowel disease (IBD) is a multifactorial and complex condition of the gastrointestinal tract shaped by host genetics, immune dysregulation, gut microbiota and environmental determinants, with a steadily rising global prevalence.
Francesca Gorini, Alessandro Tonacci
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Novel selenoprotein neighborhoods suggest specialized biochemical processes [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Daniel H. Haft, Igor Tolstoy
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Selenoprotein: Potential Player in Redox Regulation in Chlamydomonas reinhardtii
Antioxidants, 2022 Selenium (Se) is an essential micro-element for many organisms, including Chlamydomonas reinhardtii, and is required in trace amounts. It is obtained from the 21st amino acid selenocysteine (Sec, U), genetically encoded by the UGA codon.
Sandip A. Ghuge +2 more
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Frontiers in Neuroscience, 2021 Selenium (Se) and its compounds have been reported to have great potential in the prevention and treatment of Alzheimer’s disease (AD). However, little is known about the functional mechanism of Se in these processes, limiting its further clinical ...
Zhong-Hao Zhang +4 more
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