Results 31 to 40 of about 10,333 (214)
Selenoproteins in Cancer Etiology [PDF]
, 2016 Selenium exerts its functions mainly through its incorporation into selenoproteins, which contain the amino acid selenocysteine. Animal and epidemiological, but not supplementation studies, have provided evidence supporting the role of selenium in ...
Dede N. Ekoue (7921826)
core +7 more sources
Selenoproteins in the Human Placenta: How Essential Is Selenium to a Healthy Start to Life?
, 2022 Selenium is an essential trace element required for human health, and selenium deficiency has been associated with many diseases. The daily recommended intake of selenium is 60 µg/day for adults, which increases to 65 µg/day for women when ...
Claire Hogan +3 more
core +1 more source
Journal of Animal Science and Biotechnology, 2023 Background The skeletal muscle of pigs is vulnerable to oxidative damage, resulting in growth retardation. Selenoproteins are important components of antioxidant systems for animals, which are generally regulated by dietary selenium (Se) level.
Jinzhong Jing +12 more
doaj +1 more source
Deciphering the Role of Selenoprotein M
Antioxidants, 2023 Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes +4 more
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Environmental and Circadian Regulation Combine to Shape the Rhythmic Selenoproteome
Cells, 2022 The circadian clock orchestrates an organism’s endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet’s light/dark cycle on the generation of ...
Holly Kay +2 more
doaj +1 more source
Selenoproteins are essential for proper keratinocyte function and skin development. [PDF]
PLoS ONE, 2010 Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin.
Aniruddha Sengupta +6 more
doaj +1 more source
Cells, 2023 Cardiac lipotoxicity is an important contributor to cardiovascular complications during obesity. Given the fundamental role of the endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection and for the ...
Carmine Rocca +19 more
doaj +1 more source
Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery
, 2021 Selenium is incorporated into selenoproteins as the 21st amino acid selenocysteine (Sec). There are 25 selenoproteins encoded in the human genome, and their synthesis requires a dedicated machinery.
Didac Santesmasses, Vadim N. Gladyshev
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Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
Molecules, 2023 Living organisms use selenium mainly in the form of selenocysteine in the active site of oxidoreductases. Here, selenium’s unique chemistry is believed to modulate the reaction mechanism and enhance the catalytic efficiency of specific enzymes in ways ...
Luisa B. Maia +3 more
doaj +1 more source
Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
Frontiers in Nutrition, 2021 Observational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this ...
Kaitlin Day +3 more
doaj +1 more source