Bioinformatics of Selenoproteins
Antioxidants & Redox Signaling, 2020 Significance: Bioinformatics has brought important insights into the field of selenium research. The progress made in the development of computational tools in the last two decades, coordinated with growing genome resources, provided new opportunities to study selenoproteins.
Didac, Santesmasses +2 more
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Are there functional consequences of a reduction in selenium intake in UK subjects? [PDF]
, 2004 Dietary Se levels in the UK have fallen over the last 20 years and recent surveys indicate that average Se intakes are 30-40 microg/d, which is well below the current UK reference nutrient intake for adult men (75 microg/d) or women (60 microg/d ...
Anne McArdle +13 more
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Selenoproteins are essential for proper keratinocyte function and skin development. [PDF]
PLoS ONE, 2010 Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin.
Aniruddha Sengupta +6 more
doaj +1 more source
Cells, 2023 Cardiac lipotoxicity is an important contributor to cardiovascular complications during obesity. Given the fundamental role of the endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection and for the ...
Carmine Rocca +19 more
doaj +1 more source
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
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Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
Molecules, 2023 Living organisms use selenium mainly in the form of selenocysteine in the active site of oxidoreductases. Here, selenium’s unique chemistry is believed to modulate the reaction mechanism and enhance the catalytic efficiency of specific enzymes in ways ...
Luisa B. Maia +3 more
doaj +1 more source
Selenium supplementation for the primary prevention of cardiovascular disease [PDF]
, 2013 Background: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and have the potential to prevent chronic diseases including cardiovascular disease (CVD).
Clarke, Aileen +5 more
core +1 more source
Biomarkers of selenium status in dogs [PDF]
, 2016 Background: Inadequate dietary selenium (Se) intake in humans and animals can lead to long term health problems, such as cancer. In view of the owner's desire for healthy longevity of companion animals, the impact of dietary Se provision on long term ...
Du Laing, Gijs +5 more
core +2 more sources
Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
Frontiers in Nutrition, 2021 Observational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this ...
Kaitlin Day +3 more
doaj +1 more source
Impact of treatment planning target volumen (PTV) size on radiation induced diarrhoea following selenium supplementation in gynecologic radiation oncology - a subgroup analysis of a multicenter, phase III trial [PDF]
, 2013 Background: In a previous analysis (Int J Radiat Oncol Biol Phys 70:828-835,2010), we assessed whether an adjuvant supplementation with selenium (Se) improves Se status and reduces the radiation-induced side-effects of patients treated by adjuvant ...
Adamietz, Irenäus A. +14 more
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