Results 1 to 10 of about 20,846 (213)
An atlas of plant selenium metabolism. [PDF]
New PhytolSummary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
van der Woude J +3 more
europepmc +2 more sources
Retinal Gatekeepers: Molecular Mechanism and Therapeutic Role of Cysteine and Selenocysteine. [PDF]
BiomoleculesOxidative stress is a key contributor to retinal degeneration, as the retina is highly metabolically active and exposed to constant light stimulation. This review explores the crucial roles of cysteine and selenocysteine in redox homeostasis and retinal ...
Maceroni E +4 more
europepmc +2 more sources
Novel selenoprotein neighborhoods suggest specialized biochemical processes. [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Haft DH, Tolstoy I.
europepmc +2 more sources
Antioxidants, 2019 The enzyme selenocysteine β-lyase (SCLY) was first isolated in 1982 from pig livers, followed by its identification in bacteria. SCLY works as a homodimer, utilizing pyridoxal 5’-phosphate as a cofactor, and catalyzing the specific ...
Lucia A. Seale
doaj +3 more sources
Facile Recoding of Selenocysteine in Nature [PDF]
Angewandte Chemie - International Edition, 2016 AbstractSelenocysteine (Sec or U) is encoded by UGA, a stop codon reassigned by a Sec‐specific elongation factor and a distinctive RNA structure. To discover possible code variations in extant organisms we analyzed 6.4 trillion base pairs of metagenomic sequences and 24 903 microbial genomes for tRNASec species.
Takahito Mukai +2 more
exaly +6 more sources
Selenocysteine-containing proteins in mammals
Journal of Biomedical Science, 1999 Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words.
Vadim N Gladyshev
exaly +4 more sources
Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation. [PDF]
BiomoleculesAging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems.
Pace M +5 more
europepmc +2 more sources
Fermentation, 2023 Lactic acid bacteria (LAB) resist sodium selenite of concentrations greater than 100 mg/L in fermentation media. Selenium affects the growth rate, but once the microorganism absorbs selenium, this element is converted through a complex mechanism into ...
Meyli Claudia Escobar-Ramírez +5 more
doaj +1 more source
Selective selC-independent selenocysteine incorporation into formate dehydrogenases. [PDF]
PLoS ONE, 2013 The formate dehydrogenases (Fdh) Fdh-O, Fdh-N, and Fdh-H, are the only proteins in Escherichia coli that incorporate selenocysteine at a specific position by decoding a UGA codon.
Michael Zorn +4 more
doaj +1 more source
Deciphering the Role of Selenoprotein M
Antioxidants, 2023 Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes +4 more
doaj +1 more source