Results 41 to 50 of about 11,168 (173)
Mechanisms Affecting the Biosynthesis and Incorporation Rate of Selenocysteine
Molecules, 2021 Selenocysteine (Sec) is the 21st non-standard proteinogenic amino acid. Due to the particularity of the codon encoding Sec, the selenoprotein synthesis needs to be completed by unique mechanisms in specific biological systems.
Jing-Jing Peng +4 more
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Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
Molecules, 2023 Living organisms use selenium mainly in the form of selenocysteine in the active site of oxidoreductases. Here, selenium’s unique chemistry is believed to modulate the reaction mechanism and enhance the catalytic efficiency of specific enzymes in ways ...
Luisa B. Maia +3 more
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ClinicsOBJECTIVE: The free radical theory of aging suggests that cellular oxidative damage caused by free radicals is a leading cause of aging. In the present study, we examined the effects of a well-known anti-oxidant amino acid derivative, selenocysteine, in ...
Jun-Sung Kim +2 more
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Viruses, 2021 Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins +3 more
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Selenocysteine inserting tRNAs: an overview [PDF]
FEMS Microbiology Reviews, 1999 One of the recent discoveries in protein biosynthesis was the finding that selenocysteine, the 21st amino acid, is cotranslationally inserted into polypeptides under the direction of a UGA codon assisted by a specific structural signal in the mRNA. The key to selenocysteine biosynthesis and insertion is a special tRNA species, tRNA(Sec).
S, Commans, A, Böck
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Animal, 2011 The objective of this study was to determine the concentration of total selenium (Se) and proportions of total Se comprised as selenomethionine (SeMet) and selenocysteine (SeCys) in the tissues of female turkeys offered diets containing graded additions ...
D.T. Juniper, R.H. Phipps, G. Bertin
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Electrochemical Modification of Polypeptides at Selenocysteine
Angewandte Chemie, 2023 AbstractMild strategies for the selective modification of peptides and proteins are in demand for applications in therapeutic peptide and protein discovery, and in the study of fundamental biomolecular processes. Herein, we describe the development of an electrochemical selenoetherification (e‐SE) platform for the efficient site‐selective ...
Angus S. Mackay +11 more
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Selenium Metabolism and Selenoproteins in Prokaryotes: A Bioinformatics Perspective
Biomolecules, 2022 Selenium (Se) is an important trace element that mainly occurs in the form of selenocysteine in selected proteins. In prokaryotes, Se is also required for the synthesis of selenouridine and Se-containing cofactor. A large number of selenoprotein families
Yan Zhang +5 more
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Recoding the Genetic Code with Selenocysteine [PDF]
Angewandte Chemie International Edition, 2013 AbstractSelenocysteine (Sec) is naturally incorporated into proteins by recoding the stop codon UGA. Sec is not hardwired to UGA, as the Sec insertion machinery was found to be able to site‐specifically incorporate Sec directed by 58 of the 64 codons.
Markus J, Bröcker +4 more
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Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells
Biomolecular Concepts, 2017 Selenium is an essential trace element due to its incorporation into selenoproteins with important biological functions. However, at high doses it is toxic. Selenium toxicity is generally attributed to the induction of oxidative stress.
Lazard Myriam +3 more
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