Selenomethionine metabolism and its toxicity in yeast
Biomolecular Concepts, 2013 The importance of selenium for organisms can be explained by its existence as selenocysteine in the catalytic centers of glutathione peroxidase and thioredoxin reductase. Another selenoamino acid, selenomethionine, is the major form of selenium in foods,
Toshihiko Kitajima, Yasunori Chiba
exaly +4 more sources
Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity [PDF]
Cell Death and DiseaseFerroptosis is an iron-dependent form of nonapoptotic cell death driven by lipid peroxidation. The selenium-dependent glutathione peroxidase 4 (GPX4) serves as the central regulator of ferroptosis through enzymatic reduction of phospholipid ...
Chaoyi Xia +7 more
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Vitamin E Intake Modulates the Effect of Selenomethionine on Sexual Function and Depressive Symptoms in Reproductive-Age Women with Euthyroid Autoimmune Thyroiditis: A Pilot Study [PDF]
AntioxidantsOxidative stress appears to be implicated in both the initiation and progression of autoimmune thyroiditis. Selenomethionine, which exhibits antioxidant properties, has been shown to reduce thyroid antibody titers in patients with autoimmune thyroiditis.
Robert Krysiak +5 more
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Selenomethionine as an expressible handle for bioconjugations [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The manipulation of proteins in a site-selective manner underpins much of modern protein chemistry. A careful evaluation of selenomethionine benzylation led to the identification of a highly efficient bromobenzyl linker for protein bioconjugation.
Chenxi Lu, Kyle Knouse, Philip Dawson
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PlantsAn in-depth understanding of Se uptake and metabolism in plants is necessary for developing Se biofortification strategies. Thus, hydroponic experiments were conducted to investigate the associated processes and mechanisms of organic Se (selenomethionine (SeMet) and selenomethionine-oxide (SeOMet)) uptake, translocation, transformation and their ...
Huafen Li, Qingqing Huang, Qi Wang
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Elucidating the Effects of Selenium Enrichment on the Structure and Antioxidant Properties of Selenium-Containing Proteins in Yeast Cells [PDF]
AntioxidantsSelenium (Se) enrichment in yeast represents a promising strategy for producing organic Se with high bioavailability. However, a systematic understanding of how Se incorporation alters intact protein structure and function across diverse strains remains ...
Lixia He +5 more
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Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota
Frontiers in Microbiology, 2022 Either selenium or serine could modulate glucose homeostasis, however, whether there are synergistic effects of selenium with serine on diabetes remains to be unknown.
Xiaoyan Cui +3 more
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Ecotoxicology and Environmental Safety, 2022 Ammonia has been reported to have a variety of toxicity to aquatic animals, farm animals and humans. However, its potential toxicity on the intestines remains unknown. L-selenomethionine is one of the important organic selenium sources.
Xinxin Zhang +4 more
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Influence of selenomethionine and omega-3 fatty acid on serum mineral profile and nutrient utilization of broiler chicken [PDF]
Veterinary World, 2015 Aim: This study was conducted to investigate the effect of selenomethionine and omega-3 fatty acid on serum mineral profile and nutrient utilization of broiler chicken.
Pankaj Kumar +3 more
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Shipin gongye ke-ji, 2023 Objective: To screen and optimize the method for preparing three-dimensional structural samples of restriction endonuclease Bsa I. Methods: In this study, the Escherichia coli expression system was employed to express the Bsa I protein and its ...
Hai ZHU +8 more
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