Results 1 to 10 of about 14,403 (240)

Selenoprotein Gene Nomenclature [PDF]

Journal of Biological Chemistry, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and
Gladyshev, Vadim, Arnér, Elias, Berry, Marla, Brigelius-Flohé, Regina, Bruford, Elspeth, Burk, Raymond, Carlson, Bradley, Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul, Diamond, Alan, Driscoll, Donna, Ferreiro, Ana, Flohé, Leopold, Green, Fiona, Guigó, Roderic, Handy, Diane, Hatfield, Dolph, Hesketh, John, Hoffmann, Peter, Holmgren, Arne, Hondal, Robert, Howard, Michael, Huang, Kaixun, Kim, Hwa-Young, Kim, Ick Young, Köhrle, Josef, Krol, Alain, Kryukov, Gregory, Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Liu, Qiong, Lescure, Alain, Lobanov, Alexei, Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Sandeep Prabhu, K., Rayman, Margaret, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward, Schomburg, Lutz, Schweizer, Ulrich, Simonović, Miljan, Sunde, Roger, Tsuji, Petra, Tweedie, Susan, Ursini, Fulvio, Whanger, Philip, Zhang, Yan   +52 more
core   +15 more sources

eIF3 Interacts with Selenoprotein mRNAs [PDF]

Biomolecules, 2022
The synthesis of selenoproteins requires the co-translational recoding of an in-frame UGASec codon. Interactions between the Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2) in the 3′untranslated region (3′UTR) of ...
Hassan Hayek, Gilbert Eriani, Christine Allmang   +2 more
doaj   +4 more sources

Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans [PDF]

Frontiers in Nutrition, 2021
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura   +13 more
doaj   +3 more sources

Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. [PDF]

PLoS Computational Biology
Genome annotations provide the essential framework for genomic analyses, capturing our current knowledge of gene structure and function as inferred from computational predictions and experimental evidence.
Max Ticó, Emerson Sullivan, Roderic Guigó, Marco Mariotti   +3 more
doaj   +2 more sources

Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma [PDF]

Tumor Biology, 2017
There is an obvious need to diagnose hepatocellular carcinoma using novel non-invasive and sensitive biomarkers. In this regard, the aim of this study was to evaluate and correlate both relative quantification of microRNA-7 using quantitative real time ...
Marwa Tarek, Manal Louis Louka, Eman Khairy, Randa Ali-Labib, Doaa Zakaria Zaky, Iman F Montasser   +5 more
doaj   +2 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis [PDF]

Advanced Science
Selenium is an essential trace element whose dysregulation is associated with diverse disease risks; however, its specific role in hepatic metabolism remains poorly defined.
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
doaj   +2 more sources

The semisynthesis of nucleolar human selenoprotein H [PDF]

, 2023
The human selenoprotein H is the only selenocysteine-containing protein that is located in the cell’s nucleolus. In vivo studies have suggested that it plays some role in DNA binding, consumption of reactive oxygen species, and may serve as a safeguard ...
Rebecca , Notis Dardashti, Norman, Metanis   +1 more
core   +1 more source

TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

Redox Biology, 2023
TXNL1 (also named TRP32, for thioredoxin related protein of 32 kDa) is a cytosolic thioredoxin-fold protein expressed in all cell types and conserved from yeast to mammals, but with yet poorly known function.
Attila Andor, Mahendravarman Mohanraj, Zsuzsanna Anna Pató, Katalin Úri, Beáta Biri-Kovács, Qing Cheng, Elias S.J. Arnér   +6 more
doaj   +1 more source

Selenoproteins [PDF]

Journal of Biological Chemistry, 2009
Selenium is an essential micronutrient for man and animals. The role of selenium has been attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine (Sec, U). Sec is encoded by TGA in DNA. A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide ...
Jun, Lu, Arne, Holmgren
openaire   +2 more sources

Selenoproteins in Health

Molecules, 2023
Selenium (Se) is a naturally occurring essential micronutrient that is required for human health. The existing form of Se includes inorganic and organic. In contrast to the inorganic Se, which has low bioavailability and high cytotoxicity, organic Se exhibits higher bioavailability, lower toxicity, and has a more diverse composition and structure. This
Ziqi Qi, Alex Duan, Ken Ng
openaire   +4 more sources