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Selenoprotein Gene Nomenclature [PDF]
Journal of Biological Chemistry, 2016 The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Vadim N Gladyshev +2 more
exaly +13 more sources
Copper interferes with selenoprotein synthesis and activity
Redox Biology, 2020 Selenium and copper are essential trace elements for humans, needed for the biosynthesis of enzymes contributing to redox homeostasis and redox-dependent signaling pathways.
Maria Schwarz +8 more
doaj +4 more sources
Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis [PDF]
Advanced ScienceSelenium is an essential trace element whose dysregulation is associated with diverse disease risks; however, its specific role in hepatic metabolism remains poorly defined.
Yuwei Zhang +11 more
doaj +3 more sources
Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia
Scientific Reports, 2023 There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological ...
Marco Vinceti +8 more
doaj +2 more sources
Redox Biology, 2021 Selenium (Se) deficiency and poor plasma Se levels can cause cardiovascular diseases by decreasing selenoprotein levels. Neutrophil extracellular traps (NETs) may be the vicious cycle center of inflammation in vasculitis. Here, we show that Se deficiency
Qianru Chi, Yiming Zhang, Shi-Wen Xu
exaly +2 more sources
Biomedicines, 2022 The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a ...
Rachid Skouta
exaly +2 more sources
Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. [PDF]
PLoS Computational BiologyGenome annotations provide the essential framework for genomic analyses, capturing our current knowledge of gene structure and function as inferred from computational predictions and experimental evidence.
Max Ticó +3 more
doaj +2 more sources
Antioxidants and Redox Signaling, 2020 Significance: Selenoprotein P functions as a redox protein through its intrinsic thioredoxin domain and by distributing selenium to intracellular glutathione peroxidases, that is, glutathione peroxidase 1 and 4.
Toshinari Takamura
exaly +2 more sources
Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. [PDF]
PLoS ONE, 2018 Rodents and humans have 24-25 selenoproteins, and these proteins contain the 21st amino acid, selenocysteine, incorporated co-translationally into the peptide backbone in a series of reactions dependent on at least 6 unique gene products. In selenium (Se)
Roger A Sunde
doaj +2 more sources
Nature Communications, 2017 Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and ...
Yuichiro Mita +15 more
doaj +2 more sources