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Selenium and Selenoproteins in Health

Biomolecules, 2023
Selenium is a trace mineral that is essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in the body in the form of selenoproteins, which are best known for their redox activity and anti-inflammatory properties.
Fan Zhang, Xuelian Li, Yumiao Wei
openaire   +3 more sources

Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice

Antioxidants, 2022
Cisplatin is one of the most active chemotherapy drugs to treat solid tumors. However, it also causes various side effects, especially nephrotoxicity, in which oxidative stress plays critical roles.
Shuang Liu, Xing Wen, Qihan Huang, Minghui Zhu, Jun Lu   +4 more
doaj   +1 more source

Selenoprotein-Transgenic Chlamydomonas reinhardtii [PDF]

, 2013
Selenium (Se) deficiency is associated with the occurrence of many diseases. However, excessive Se supplementation, especially with inorganic Se, can result in toxicity. Selenoproteins are the major forms of Se in vivo to exert its biological function.
Qintang Hou, Jing Tian, Shi Qiu, Zhangli Hu, Jiazuan Ni, Qiong Liu   +5 more
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Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes [PDF]

, 2022
Selenoprotein S (SelS), a member of the selenoprotein family, is mainly located on the endoplasmic reticulum (ER) membrane. SelS is involved in a variety of biological processes, including oxidative stress, inflammation, glucose metabolism regulation ...
Chen, Yonghui, Liu, Yinan, Chen, Chen, Li, Zhengzheng, Wang, Hui, Wang, Mengying, He, Ying, Shi, Yawen, Zhang, Ying, Zhang, Meng, Mi, Ge, Chen, Jinghong   +11 more
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Copper interferes with selenoprotein synthesis and activity

Redox Biology, 2020
Selenium and copper are essential trace elements for humans, needed for the biosynthesis of enzymes contributing to redox homeostasis and redox-dependent signaling pathways.
Maria Schwarz, Kristina Lossow, Katja Schirl, Julian Hackler, Kostja Renko, Johannes Florian Kopp, Tanja Schwerdtle, Lutz Schomburg, Anna Patricia Kipp   +8 more
doaj   +1 more source

Selenium – a scoping review for Nordic Nutrition Recommendations 2023

Food & Nutrition Research, 2023
Selenium is an essential trace element in humans, critical to the normal physiology in all animal species. The main form of selenium in food is selenomethionine, selenocysteine and a variety of organic compounds, while inorganic salts mainly occur in ...
Jan Alexander, Ann-Karin Olsen
doaj   +1 more source

Reactive Human Plasma Glutathione Peroxidase Mutant with Diselenide Bond Succeeds in Tetramer Formation

Antioxidants, 2022
Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan, Qi Yan, Jian Song, Jingyan Wei   +3 more
doaj   +1 more source

Hypermethylated-capped selenoprotein mRNAs in mammals. [PDF]

, 2014
Mammalian mRNAs are generated by complex and coordinated biogenesis pathways and acquire 5'-end m7G caps that play fundamental roles in processing and translation.
Wurth, L. (L), Verheggen, C. (C), Gribling-Burrer, A. (A) S. (S), Krol, A. (Alain), Takeuchi, A. (A), Allmang, C. (C), Leichter, M. (M), Martin, F. (Franck), Bertrand, E. (E), Baudrey, S. (Stéphanie)   +9 more
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Selenoproteins and cardiovascular stress [PDF]

Thrombosis and Haemostasis, 2015
SummaryDietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others.
Aaron H, Rose, Peter R, Hoffmann
openaire   +2 more sources

Table_1_Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.xlsx [PDF]

, 2021
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe (2898251), Hiroyuki Nakamura (200082), Takehiro Kanamori (8255321), Hiromasa Tsujiguchi (4258522), Atsushi Tajima (40311), Akinori Hara (452250), Takayuki Kannon (10175561), Yumie Takeshita (307060), Hiroki Asakura (4258519), Toshinari Takamura (158655), Kiyo-aki Ishii (10175564), Tatsuya Yamashita (3067323), Shuichi Kaneko (156576), Hiroaki Takayama (2530507)   +13 more
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