BMC Genomics, 2010 Background Computational methods for identifying selenoproteins have been developed rapidly in recent years. However, it is still difficult to identify the open reading frame (ORF) of eukaryotic selenoprotein gene, because the TGA codon for a ...
Jiang Liang, Liu Qiong, Ni Jiazuan
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Knockdown of selenocysteine-specific elongation factor in Amblyomma maculatum alters the pathogen burden of Rickettsia parkeri with epigenetic control by the Sin3 histone deacetylase corepressor complex. [PDF]
PLoS ONE, 2013 Selenocysteine is the 21st naturally-occurring amino acid. Selenoproteins have diverse functions and many remain uncharacterized, but they are typically associated with antioxidant activity.
Steven W Adamson +4 more
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Accurate quantification of selenoproteins in human plasma/serum by isotope dilution ICP-MS : focus on selenoprotein P [PDF]
, 2017 Acknowledgements The research leading to these results was funded by the EMRP Joint Research Project “Metrology for metalloproteins” (HLT-05 2012). The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union.Peer ...
Busto, M. Estela del Castillo +8 more
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Endocrinology, 2020 Selenium (Se) apart from iodine, iron and calcium is one of the nutrient-derived key elements strongly impacting the endocrine system. However, no specific hormonal 'feedback' regulation for Se status has yet been identified in contrast to the fine-tuned
J. Köhrle
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Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]
, 2009 Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H. +5 more
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Modern concept of biological identification of selenoproteins
Regulatory Mechanisms in Biosystems, 2018 Humans possess 25 selenoproteins, approximately half of which are enzymes (selenoenzymes) required for preventing, regulating, or reversing oxidative damage, while others participate in providing calcium metabolism, thyroid hormone maintenance, protein ...
N. V. Stanishevska
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Beyond antioxidants: Selenium and skeletal muscle mitochondria
Frontiers in Veterinary Science, 2022 The element, Selenium (Se), has an essential nutritive and biological role as a trace mineral known primarily for its vital antioxidant functions as a constituent of the selenoenzyme, glutathione peroxidase.
Lauren T. Wesolowski +2 more
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Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins).
A. Cox +18 more
semanticscholar +3 more sources
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
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Selenium supplementation for the primary prevention of cardiovascular disease [PDF]
, 2013 Background: Selenium is a key component of a number of selenoproteins which protect against oxidative stress and have the potential to prevent chronic diseases including cardiovascular disease (CVD).
Clarke, Aileen +5 more
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