Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P [PDF]
Scientific Reports, 2017 Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading.
Kostja Renko +11 more
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Autoimmunity to selenoprotein P predicts breast cancer recurrence [PDF]
Redox Biology, 2022 Background: Low concentrations of serum selenium (Se) and its main transporter selenoprotein P (SELENOP) are associated with a poor prognosis following breast cancer diagnosis.
Kamil Demircan +11 more
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Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia [PDF]
Scientific Reports, 2023 There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological ...
Marco Vinceti +8 more
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Selenoprotein P controls oxidative stress in cornea. [PDF]
PLoS ONE, 2010 The ocular surface is always attacked by oxidative stress, and cornea epithelial cells are supposed to have their own recovery system against oxidative stress.
Akihiro Higuchi +4 more
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Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood.
Ryohei Takeishi +18 more
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The selenoprotein P/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis [PDF]
Redox BiologyThe essential trace element selenium (Se) plays a significant role in redox homeostasis, while Se is very reactive and has a potent toxicity. Understanding the molecular machinery that supports Se metabolism is important for the both physiological and ...
Atsuya Ichikawa +9 more
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The Association of Plasma Selenium and Selenoprotein P Levels with Depression Severity and Anxiety Symptoms Among Medical Students in Latvia [PDF]
MedicinaBackground and Objectives: Oxidative stress has been identified as a key process involved in different diseases, particularly depression. Selenium (Se) protects against oxidative stress, one of the pathogenic mechanisms involved in affective disorders ...
Zanda Birģele +5 more
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Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study [PDF]
Scientific ReportsEssential trace elements, such as iron (Fe) and selenium (Se), play physiological roles in our body, whereas environmental toxic metals, such as arsenic (As), cadmium (Cd), and mercury (Hg), are known to be associated with various disease risks. However,
Yoshiro Saito +11 more
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Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation [PDF]
Frontiers in Nutrition, 2021 Selenoprotein P (SELENOP1) is a selenium-rich antioxidant protein involved in extracellular transport of selenium (Se). SELENOP1 also has metal binding properties.
Arlene C. P. Kiyohara +7 more
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Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P [PDF]
Nature Communications, 2023 Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium and copper metabolism are inversely regulated,
Maria Schwarz +24 more
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