Results 11 to 20 of about 10,363 (168)

Selenoprotein P controls oxidative stress in cornea. [PDF]

PLoS ONE, 2010
The ocular surface is always attacked by oxidative stress, and cornea epithelial cells are supposed to have their own recovery system against oxidative stress.
Akihiro Higuchi, Kazuhiko Takahashi, Masaki Hirashima, Tetsuya Kawakita, Kazuo Tsubota   +4 more
doaj   +4 more sources

Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P [PDF]

EMBO Reports
Muscle regeneration is impaired with aging, due to both intrinsic defects of muscle stem cells (MuSCs) and alterations of their niche. Here, we monitor the cells constituting the MuSC niche over time in young and old regenerating mouse muscle.
Dieu-Huong Hoang, Jessica Bouvière, Johanna Galvis, Pauline Moullé, Orane Mercier, Eugenia Migliavacca, Ananga Ghosh, Gaëtan Juban, Sophie Liot, Pascal Stuelsatz, Fabien Le Grand, Jérôme N Feige, Rémi Mounier, Bénédicte Chazaud   +13 more
doaj   +3 more sources

Circulating selenoprotein P levels predict glucose‐lowering and insulinotropic effects of metformin, but not alogliptin: A post‐hoc analysis [PDF]

Journal of Diabetes Investigation, 2023
Aims/Introduction Selenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase ...
Yumie Takeshita, Takeo Tanaka, Hiroaki Takayama, Yuki Kita, Hisanori Goto, Yujiro Nakano, Yoshiro Saito, Toshinari Takamura   +7 more
doaj   +2 more sources

Investigation of The Placental Levels of Vascular Endothelial Growth Factor B and Selenoprotein P and Their Relation with Birth Weight in Patients with Pre-eclampsia: A Case-Control Study [PDF]

International Journal of Fertility and Sterility
Background: Pre-eclampsia is a serious medical condition characterised by high blood pressure and signs of organdamage that is associated with adverse pregnancy outcomes, including low birth weight.
Hadi Eslahi, Mohsen Saravani, Mansour Shahraki, Abolfazl Payandeh, Mahnaz Rezaei, Marzieh Ghasemi, Saeedeh Salimi, Mahjob Sargazi-Taghazi   +7 more
doaj   +2 more sources

A Pan-Cancer Analysis of the Role of Selenoprotein P mRNA in Tumorigenesis [PDF]

International Journal of General Medicine, 2021
Yanni Yang,1– 3,* Daning Li,1,* Wentao Wu,1 Dingxing Huang,1 Haishi Zheng,3 Yirixiati Aihaiti3 1School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China; 2Shaanxi University of ...
Yang Y, Li D, Wu W, Huang D, Zheng H, Aihaiti Y   +5 more
doaj   +2 more sources

A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease [PDF]

Frontiers in Nutrition, 2022
BackgroundKeshan disease (KD) is strongly associated with selenium deficiency. Selenoprotein P (SELENOP) is a recognized molecular biomarker of selenoproteins and an important indicator of selenium nutrition.
Yuehui Jia, Ruixiang Wang, Shengqi Su, Lei Qi, Yuanyuan Wang, Yanan Wang, Yanan Wang, Yuanjie Zou, Yuanjie Zou, Xu Liu, Xu Liu, Yiyi Zhang, Yiyi Zhang, Jie Hou, Hongqi Feng, Qi Li, Tong Wang   +16 more
doaj   +2 more sources

Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans

Frontiers in Nutrition, 2021
Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction.
Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura   +13 more
doaj   +1 more source

The selenium content of SEPP1 versus selenium requirements in vertebrates [PDF]

PeerJ, 2015
Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we
Sam Penglase, Kristin Hamre, Ståle Ellingsen   +2 more
doaj   +2 more sources

Analysis of the selenoprotein P (rs7579) gene polymorphism and expression in patients with chronic pancreatitis combined with hypothyroidism

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. The specific role and place of genetic factors in the development of chronic pancreatitis and hypothyroidism, which determine the activity of glutathione antioxidant protection, have not been clarified. They are interconnected with changes in
V.V. Ratsa, O.I. Fediv, L.P. Sydorchuk, Z.I. Rossokha, O.I. Sydorchuk, V.T. Stepan, I.O. Buzdugan   +6 more
doaj   +1 more source

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements [PDF]

Open Biology, 2016
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously
Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E. Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T. Howard, Mario Capecchi, Roderic Guigó, Raymond F. Burk, John F. Atkins   +13 more
doaj   +1 more source