Results 21 to 30 of about 17,575 (209)
The selenium content of SEPP1 versus selenium requirements in vertebrates [PDF]
PeerJ, 2015 Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. For vertebrates, the Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we
Sam Penglase +2 more
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Frontiers in Animal Science, 2022 Many supplemental Se-dependent metabolic effects are mediated through the function of selenoproteins. The full complement and relative abundance of selenoproteins expressed by highly metabolic cattle tissues have not been characterized in cattle.
Qing Li +3 more
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Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements [PDF]
Open Biology, 2016 Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously
Sen Wu +13 more
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Mìžnarodnij Endokrinologìčnij Žurnal, 2023 Background. The specific role and place of genetic factors in the development of chronic pancreatitis and hypothyroidism, which determine the activity of glutathione antioxidant protection, have not been clarified. They are interconnected with changes in
V.V. Ratsa +6 more
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Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience [PDF]
Pediatric Sciences Journal, 2022 Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR).
Hend Mehawed Soliman +3 more
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Selenoprotein P in colitis-associated carcinoma [PDF]
Molecular & Cellular Oncology, 2016 Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative ...
Sarah P, Short +2 more
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Direct Interaction between Selenoprotein P and Tubulin [PDF]
International Journal of Molecular Sciences, 2014 Selenium (Se), an essential trace element for human health, mainly exerts its biological function via selenoproteins. Among the 25 selenoproteins identified in human, selenoprotein P (SelP) is the only one that contains multiple selenocysteines (Sec) in the sequence, and has been suggested to function as a Se transporter.
Du, Xiubo +6 more
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Domain structure of bi-functional selenoprotein P [PDF]
Biochemical Journal, 2004 Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the remaining nine localized in the C-terminal third part.
Yoshiro, Saito +5 more
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Selenoprotein P regulation by the glucocorticoid receptor [PDF]
BioMetals, 2009 Maintenance of the antioxidant activity of selenoproteins is one potential mechanism of the beneficial health effects of selenium. Selenoprotein P is the primary selenium distribution protein of the body as well as the major selenium containing protein in serum.
Colleen, Rock, Philip J, Moos
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BMC Genomics, 2010 Background Computational methods for identifying selenoproteins have been developed rapidly in recent years. However, it is still difficult to identify the open reading frame (ORF) of eukaryotic selenoprotein gene, because the TGA codon for a ...
Jiang Liang, Liu Qiong, Ni Jiazuan
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