Results 31 to 40 of about 10,363 (168)
Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P
Scientific Reports, 2017 Selenoprotein biosynthesis relies on the co-translational insertion of selenocysteine in response to UGA codons. Aminoglycoside antibiotics interfere with ribosomal function and may cause codon misreading.
Kostja Renko +11 more
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Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma
Tumor Biology, 2017 There is an obvious need to diagnose hepatocellular carcinoma using novel non-invasive and sensitive biomarkers. In this regard, the aim of this study was to evaluate and correlate both relative quantification of microRNA-7 using quantitative real time ...
Marwa Tarek +5 more
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Poultry Science, 2022 : This study's objective was to investigate the effects of dietary Se (in the form of selenomethionine) on the antioxidant activity and selenoprotein gene expressions in layer breeder roosters.
Cheng Long +10 more
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Selenoprotein P Expression, Purification, and Immunochemical Characterization [PDF]
Journal of Biological Chemistry, 2000 Most selenoproteins contain a single selenocysteine residue per polypeptide chain, encoded by an in-frame UGA codon. Selenoprotein P is unique in that its mRNA encodes 10-12 selenocysteine residues, depending on species. In addition to the high number of selenocysteines, the protein is cysteine- and histidine-rich.
R M, Tujebajeva, J W, Harney, M J, Berry
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Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure. [PDF]
PLoS ONE, 2018 BACKGROUND:Little is known on the role of selenoprotein genes in cardiovascular disease. This study examines the associations of the SEPP1, SELENOS, TXNRD1, TXNRD2, GPX4, and SOD2 polymorphisms and selenoprotein P (SeP) and thioredoxin concentrations ...
Ewa Strauss +3 more
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Direct Interaction between Selenoprotein P and Tubulin [PDF]
International Journal of Molecular Sciences, 2014 Selenium (Se), an essential trace element for human health, mainly exerts its biological function via selenoproteins. Among the 25 selenoproteins identified in human, selenoprotein P (SelP) is the only one that contains multiple selenocysteines (Sec) in the sequence, and has been suggested to function as a Se transporter.
Du, Xiubo +6 more
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Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression
BMC Immunology, 2009 Background Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins).
Gladyshev Vadim N +8 more
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A spatial study on Keshan disease prevalence and selenoprotein P in the Heilongjiang Province, China
International Journal of Occupational Medicine and Environmental Health, 2021 Objectives Few spatial studies on Keshan disease (KD) prevalence and serum selenoprotein P (SELENOP) levels have been reported in the Heilongjiang Province, China.
Yanan Wang +8 more
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Selenoprotein P—Expression, functions, and roles in mammals [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 Selenoprotein P (Sepp1) is a secreted protein that is made up of 2 domains. The larger N-terminal domain contains 1 selenocysteine residue in a redox motif and the smaller C-terminal domain contains the other 9 selenocysteines. Sepp1 isoforms of varying lengths occur but quantitation of them has not been achieved.
Raymond F, Burk, Kristina E, Hill
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Nature Communications, 2017 Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and ...
Yuichiro Mita +15 more
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