Results 51 to 60 of about 24,108,879 (155)

Selenium and selenoprotein P1 levels are related to primary open-angle glaucoma [PDF]

Journal of Medical Biochemistry, 2014
Background: Glaucoma is a highly prevalent eye disease related to optic nerve lesions and visual field defects. Primary Open-Angle Glaucoma (POAG) is a type of glaucoma that occurs frequently with unknown etiology.
Najafi Mohammad, Nouruzi Yeganeh Morteza, Miraftabi Arezoo, Zarei Reza, Noormohammadi Isa   +4 more
doaj  

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Selenoprotein Gene Nomenclature

The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Tsuji PA, Brigelius-Flohe R, Maiorino M, Rozovsky S, Diamond AM, Huang K, Conrad M, Bruford EA, Burk RF, Lee BJ, Tweedie S, Simonovic M, Whanger PD, Lee BC, Castellano S, Sunde RA, Chavatte L, Howard MT, Driscoll DM, Lescure A, Rayman MP, Hondal RJ, Hatfield DL, Schomburg L, Hesketh J, Krol A, Hoffmann PR, Kim IY, Salinas G, Schmidt EE, Green FR, Flohe L, Gladyshev VN, Liu Q, Guigo R, Kohrle J, Holmgren A, Mariotti M, Arner ES, Ferreiro A, Kim HY, Carlson BA, Loscalzo J, Handy DE, Copeland PR, Kryukov GV, Berry MJ, Lei XG, Lobanov AV, Ursini F, Zhang Y, Prabhu KS, Schweizer U   +52 more
core   +4 more sources

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study

Journal of Translational Medicine, 2023
Introduction Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence circulating selenium may interact
Kamil Demircan, Ylva Bengtsson, Thilo Samson Chillon, Johan Vallon-Christersson, Qian Sun, Christer Larsson, Martin Malmberg, Lao H. Saal, Lisa Rydén, Åke Borg, Jonas Manjer, Lutz Schomburg   +11 more
doaj   +1 more source

Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations

Biomedicines, 2021
A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated
Jacqueline Roshelli Baker, Sushma Umesh, Mazda Jenab, Lutz Schomburg, Anne Tjønneland, Anja Olsen, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Verena Katzke, Theron Johnson, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Vittorio Simeon, Rosario Tumino, H. Bas Bueno-de-Mesquita, Inger Torhild Gram, Guri Skeie, Catalina Bonet, Miguel Rodriguez-Barranco, José María Houerta, Björn Gylling, Bethany Van Guelpen, Aurora Perez-Cornago, Elom Aglago, Heinz Freisling, Elisabete Weiderpass, Amanda J. Cross, Alicia K. Heath, David J. Hughes, Veronika Fedirko   +31 more
doaj   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Doctor of Philosophy [PDF]

, 2010
dissertationSelenium is an essential trace element that has been linked to beneficial health effects in multiple disease states. These effects have been attributed to antioxidant activity of selenoproteins; proteins containing selenium incorporated as ...
Rock, Colleen Marie
core  

Response of rat selenoprotein P to selenium administration and fate of its selenium

, 1991
Selenoprotein P is a glycoprotein that contains greater than 60% of the selenium in rat plasma. Physiological experiments were undertaken to gain insight into selenoprotein P function.
T. Bellew, K. E. Hill, R. F. Burk, R. Read   +3 more
core   +1 more source

Elucidation of the mechanism of adaptive thermogenesis disorder by selenoprotein P [PDF]

, 2021
セレノプロテインPが褐色脂肪組織での適応熱産生に与える影響を検討し、以下のことを明らかにした。 (1) セレノプロテインPが欠損したマウスは寒冷下での体温の上昇と活性型UCP1の増大を呈した。(2) セレノプロテインPを欠損した褐色脂肪細胞ではノルアドレナリン応答性の熱産生が亢進した一方、褐色脂肪細胞へのセレノプロテインP投与では熱産生が障害された。(3) 褐色脂肪細胞へのノルアドレナリン投与は熱産生を刺激する生理的な活性酸素産生を誘導した。セレノプロテインPはこの有用な活性酸素を消去した ...
高山, 浩昭, 91110, 90725227
core   +1 more source